Encapsulation of Folic Acid in Sodium Alginate-Pectin-Poly(Ethylene Oxide) Electrospun Fibers to Increase Its Stability
Notice bibliographique
Résumé
This thesis explored the use of sodium alginate-pectin-poly(ethylene oxide) electrospun fibers as a carrier to stabilize folic acid - an essential micronutrient that is susceptible to degradation when exposed to light and acidic conditions. In the first phase of this research, electrospinning behaviour of aqueous alginate-pectin solutions was investigated. Aqueous polysaccharide solutions could not be electrospun unless poly(ethylene oxide) (PEO) was added (≥20% w/w), resulting in electrospun alginate-pectin fibers that varied from fiber to fiber-bead, depending on the polymer blend ratio, and concentration of the polymer solutions. Polymer solutions properties (surface tension, viscosity, conductivity) were determined to study their effects on the electrospinning behaviour of the polymer solutions. In the second phase of this research, folic acid was incorporated into the polymer solutions and electrospun. The efficacy of these fibers in improving the stability of folic acid under different pH conditions was investigated. FTIR and NMR spectroscopies were employed to elucidate the nature of polymer-polymer and folic acid-polymer interaction. In phase three, the release behaviour of folic acid under simulated gastrointestinal conditions was evaluated. \tOverall, this research showed that electrospun fibers with different morphologies could be produced by manipulating the polymer concentration, polysaccharide/PEO blend ratio, extent of sonication treatment during sample preparation, and electrospinning process parameters. The positive effect of PEO on the electrospining of alginate-pectin fibers was attributed to its electrical conductivity and surface tension lowering effects on the polymer solutions. Electrospun fibers produced from the combination of alginate-pectin resulted in higher retention of folic acid compared to that of alginate alone. Folic acid encapsulated in crosslinked electrospun fibers achieved close to 100% retention when stored in the dark at pH 3 after 41 days of storage. Minimal release of folic acid from the electrospun fibers was observed at pH 3, although the release was significantly higher at pH 1.2. On the other hand, the release of folic acid was nearly 97% at pH 7.8, a condition that simulated the pH condition in the intestine. From NMR and FTIR data, the stabilization effect of electrospun fibers on folic acid was attributed to physical entrapment and not specific chemical interaction. \tThe research suggests that ethanol-treated crosslinked alginate-pectin electrospun fibers can potentially be used as a folic acid carrier to protect the micronutrient in food products, especially acidic food products such as fruit juices and acidified beverages.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».