9th Congress of the International Society of Nutrigenetics/Nutrigenomics (ISNN). May 17-19, 2015 Chapel Hill, N.C., USA: Abstracts
Notice bibliographique
Résumé
Background/Aims: The vitamin D receptor (VDR) gene polymorphism, Fok1 (rs10735810), may influence risk of cancers via modulation of multiple vitamin D sensitive pathways, including angiogenesis, cell proliferation and differentiation, and protection from oxidative stress.In colorectal cancer (CRC) however, results have been mixed and any association remains contentious [1][2][3][4][5][6][7].Failure to clinically exclude the presence of adenomatous polyps (AP), the benign precursor of CRC, in control cohorts may contribute to the lack of consensus.Insufficient adjustment for other potential risk factors (such as diet, smoking and alcohol intake) may also explain some of the discrepancies.Therefore, we assessed the role of the Fok1 polymorphism in modifying the risk for AP in clinically confirmed cases and controls, adjusting for a range of dietary and lifestyle variables.Methods: Blood was collected from patients undergoing routine colonoscopy (n = 258).Diagnosis of AP was used to classify cases and controls.Fok1 polymorphisms were assessed using RFLP-PCR (F = absence; f = presence of restriction site, early start codon, less transcriptionally active) [8][9].Dietary habits were estimated from food frequency questionnaires.AP incidence (OR, 95% CI) were calculated by genotype, stratified by sex and corrected for age.Additional adjustments were made for life-style factors (smoking history and alcohol intake), objective markers of diet (blood B12 and folate), and reported markers of dietary habits (including estimated dietary fibre, iron, vitamin C, calcium, vitamin D and fat intake).Regression analysis was used to examine the relationship between vitamin D and AP risk.Results: Participants were aged 18-89 (mean 62.25 ± 0.75); 44% were male.AP were detected in 57 (22%) of participants.No statistically significant relationships were found between AP and Fok1 genotype in females.In males the 'F' allele was associated with increased incidence of AP.When adjusted for age only, AP incidence was increased in 'F' homozygotes, relative to 'f' homozygotes (OR = 6.43, 1.09-123.03).Additional adjustment for lifestyle factors revealed increased AP incidence in those possessing the 'F' allele (ORs: FF = 7.59, 1.23-148.70;Ff = 6.42, 1.07-124.68).Further adjustment for dietary variables revealed similar associations.Reported vitamin D intake did not correlate with risk of AP in males or females, regardless of correction for age, smoking status, alcohol consumption or dietary factors (p > 0.05). Conclusion:In Australian males, VDR-Fok1 polymorphisms may influence the risk of AP, the benign precursor to CRC, which in turn, is likely to influence the risk of CRC.Lifestyle & dietary habits influence the strength of this association and need to be fully considered in future studies.This study offers novel insight into the potential for VDR genetics to contribute to risk for adenomatous polyps, and is the first to demonstrate a sex-specific relationship between the VDR-Fok1 polymorphism and risk for adenomatous polyps.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,003 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,002 | 0,001 |
| Science ouverte | 0,001 | 0,003 |
| Intégrité de la recherche | 0,002 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,076 | 0,038 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».