Epidemiology Of Imported Plasmodium Falciparum Infections In Returning Travelers To Calgary, 2007-2012
Notice bibliographique
Résumé
INTRODUCTION Malaria, an infectious disease transmitted by the anopheles mosquitoes, contributes to the significant morbidity and mortality in the tropics - it is responsible for over three million annual deaths 1 . With the increase in intercontinental travelling and immigration, there has been a notable rise in the number of malaria cases in industrialized countries 2 . The most prevalent imported malaria cases are caused by Plasmodium falciparum species, which is also responsible for the most virulent and lethal malaria infections in humans 1 . Calgary is the fourth largest Canadian city to have the highest number of immigrants, who consisted 30% of the total city population in 2010 3 . On average, sixty to hundred malaria cases are reported annually in Calgary as determined by the local diagnostic laboratory 3 . However, little is known about the epidemiology of the patients, such as travel history, type of prophylaxis taken and the causative Plasmodium species. Therefore, the aim of this retrospective study was to determine whether returning travellers to Calgary are vectors of drug-resistant strains of malaria and thus a critical sentinel of emerging resistance in other parts of the world. METHODS The study group comprised of patients who were positive for P. falciparum malaria between 2007 and 2012 with travel history to endemic countries. The following information was collected: pre-travel advice, reason for travel, countries with malaria visited, types of prophylaxis taken and treatment. The data were entered and stored on the Microsoft Access database. From this, the following epidemiological data were collected: gender, age, geometric mean parasitemia and parasite clearance rate. The data were calculated using SPSS, Microsoft Excel and Parasite Clearance Estimator tool by WWARN. RESULTS Between 2007 and 2012, a total of 209 cases were laboratory-confirmed in Calgary. The 58.6% of the cases were caused by P. falciparum with 119 reported cases where 68.9% were seen in males. The mean age of P.falciparum infected males was 32.5±14.1 and females, 26.5±15.0. The parasite clearance rate of eligible patients ranged from 0.0269 to 0.578 (n=31). The highest GMP of 0.878 was observed in 2007. A majority of travellers received pre-travel advice (61.3%), but 38.7% of infected patients had not taken prophylaxis. Almost a half of the patients (47.5%) were VFR travellers. Most P. falciparum infected patients had travelled to at least one country in Africa. DISCUSSION AND CONCLUSIONS During the 2007 and 2012 period, there was a moderate increase in the number of P. falciparum cases, with alternating increases and decreases each year. A linear regression performed by SPSS showed that there is a non-significant (p=0.149) but a moderately increasing trend (r=0.514) in the number of P.falciparum cases over the six years. Based on the results, the majority of patients infected with P. falciparum were, therefore: males aged 30-39, travelled to Africa to VFR, did not seek pre-travel advice, did not take prophylaxis and had an average parasite clearance rate of 0.116±0.101. One limitation of this study is the estimation of parasite clearance rate, in which the tool developed by WWARN had very specific requirements and reducing the number of eligible patients to 31.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,002 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».