Efficacy of third-line chemotherapy for recurrent ovarian, peritoneal and fallopian tube carcinoma
Notice bibliographique
Résumé
5136 Background: Various types of chemotherapy have been studied in patients with refractory/relapsing ovarian carcinoma. However there is very limited information regarding the usefulness of chemotherapy in ovarian cancer patients who have received several lines of treatment. Methods: All patients with ovarian epithelial, primary peritoneal or fallopian tube carcinoma who received at least three different types of chemotherapy in our institution were evaluated retrospectively. Those included in the analysis had to have received at least one platin-based regimen as their 1st line treatment and Topotecan as their 2nd line. The primary endpoint was response rate (RR). Responses were analysed according to the RECIST criteria for measurable disease, and the CA-125 criteria defined by the Gynecologic Cancer Intergroup (GCIG). Secondary endpoints were time to progression (TTP), disease stabilization, and overall survival (OS). Results: Fifty-two patients met our entry criteria. Ten (19.2%) had responded to Topotecan as their 2nd line treatment. Liposomal doxorubicin was the most often used third-line therapy (40.4%). The overall RR was 13.5% for third-line agent (1 CR and 6 PR). Median TTP was 50.7 weeks (95% CI 30 to 86 weeks) and disease stabilization was noted in 23% of patients with a median duration of 17.7 weeks. The median OS from the start of 3rd line therapy was 11.7 months (95% CI 7.7 to 15.3 months). It was significantly better for patients who responded to 3rd line treatment compared to non-responders (24.6 vs 7.3 months, p=0.0017). The only prognostic factor that strongly influenced the OS was the type of response to previous Topotecan (p = 0.0596) with a median OS from the start of 3rd line of 19.5 months for Topotecan responders compared to 10.3 months for the others. Conclusions: Disease response or stabilization occurs in about a third of patients receiving 3rd line treatment. The type of response to 2nd line therapy (Topotecan in this study) can help predict the responsiveness and perhaps usefulness of subsequent chemotherapy. This is the first study to show that median OS is significantly improved in responders compared to non-responders in women receiving 3rd line therapy for ovarian carcinoma. No significant financial relationships to disclose.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».