RETRACTED: Monocytes play different roles in stimulating T cells in obese diabetic individuals
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Dossier post-publication
- Nature
- Retraction
- Motif
- False/Forged Affiliation;False/Forged Authorship;Unreliable Results and/or Conclusions;
- Date
- 3/30/2023 0:00
- Signalé par OpenAlex ?
- Oui
Source : Retraction Watch, jointe par DOI. OpenAlex consigne la rétractation dans is_retracted, un booléen sur un espace d'états à au moins quatre valeurs ; il ne peut donc exprimer ni une expression de préoccupation, ni une correction, ni un rétablissement, et les rapporte comme false, ce qui se lit comme « rien à signaler ».
Résumé
Type 2 diabetes (T2D) is a chronic metabolic disorder, which was also found to involve a series of inflammatory disorders, including accumulation of macrophages and T cells in the adipose tissue, increased proinflammatory cytokine production, shifting of macrophage composition toward M1-type, and skewing of peripheral blood T cells toward IL-17 productions. However, these studies were primarily conducted in obese mouse models and/or human subjects with higher BMI, and may not reflect the role of the immune system in non-obese T2D pathogenesis. Here, we examined T cell and monocyte cytokine expression and function in both non-obese and obese T2D patients. We found that IFN-g production by circulating T cells were increased in both non-obese and obese T2D subjects, while IL-17 is only upregulated in obese T2D subjects. Also, circulating monocytes from obese T2D subjects had significantly higher IL-6 production than their counterparts in non-obese T2D subjects. Moreover, monocytes from non-obese T2D subjects could support IFN-g but not IL-17 production in vitro, while that from obese T2D subjects supported both IFN-g and IL-17 production. Together, our results revealed that the role immune system plays in T2D pathogenesis is more complicated than previously thought, and is affected by the person's BMI.
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La notice
- Revue
- International Journal of Immunopathology and Pharmacology
- Thématique
- Adipokines, Inflammation, and Metabolic Diseases
- Domaine
- Medicine
- Établissements canadiens
- University of British Columbia Hospital
- Organismes subventionnaires
- —
- Mots-clés
- Type 2 diabetesProinflammatory cytokineImmune systemPathogenesisMedicineAdipose tissueCytokineInternal medicineEndocrinologyMonocyteMacrophageImmunologyDiabetes mellitusInflammationBiologyIn vitro
- Résumé présent dans OpenAlex
- oui