Natural and synthetic hydrogels for periodontal tissue regeneration
Notice bibliographique
Résumé
Over the past few decades, there has been a great interest in periodontal regeneration therapy to restore the tissues destroyed by periodontal diseases, which are probably one of the most common bacterial infections in humans and the leading cause of tooth loss in adults. Periodontal diseases involve a set of inflammatory processes that are progressively destroying the tooth-supporting tissues (gingiva, periodontal ligament (PDL), alveolar bone and root cementum). Untreated periodontitis may cause irreversible destruction to these tissues leading to increased tooth mobility and subsequent tooth loss[1]. Currently, there is still no ideal therapeutic method to cure periodontitis or to optimally regenerate periodontal tissues in a predictable manner. Conventional mechanical or anti-infective periodontal therapies eliminate the inflammatory processes, and hinders or halts the diseases resulting generally in tissue repair without any notable signs of regeneration. Therefore, various regenerative approaches have been proposed and evaluated to restore the lost tooth-supporting tissues. These approaches included a wide range of surgical procedures and the use of various bone grafts, occlusal barrier membranes, purified protein mixtures, growth factors. Some of these approaches have achieved some success in regenerating the damaged periodontal tissues in certain ideal clinical cases; however, the outcomes are still very variable and unpredictable. Even with bone grafts, which are considered the current gold-standard material for bone regeneration, have reported failure rates up to 30% in maxillofacial and craniofacial surgeries, in addition to their drawbacks such as limited availability and donor-site morbidity. It is evident that a considerable research activity is required to improve the current periodontal therapies and to develop novel treatments to reach the ultimate goal of periodontal therapy, which is the predictable reconstruction of the lost periodontal tissues. Periodontal tissue possess the capacity to regenerate itself and substantial efforts in the tissue engineering field have been done to understand this ability in order to overcome the current limitations of therapeutic and regenerative procedures [3]. Tissue engineering is a multidisciplinary field that aims to guide body regeneration by specifically controlling the biological environment or developing biological substitutes to restore tissue functions. The damage to any tissue or organ results in the destruction and loss of extracellular matrix (ECM) with the absence of functional cells. For this reason, it is of paramount importance to restore the structure, properties, and functions of the native natural tissue. The general approach to restore the initial tissue condition is to use a three-dimensional (3D) scaffold which has the function to temporary supports the cell growth and new tissue development. The 3D scaffold may be designed as purely structural support providing with biological moieties incorporated into the scaffold to guide cell and tissue growth. Regeneration of dental/craniofacial tissues may be successfully achieved from the inimitable blend of human cells seeded biomaterial scaffolds with/without growth factors [4]. The combination of stem-cells, biomaterials, and physio-biochemical factors is the basis and major contribution of tissue engineering to regenerative medicine. In this approach, the biomaterial is critical to the regeneration of tissue since it serves as a three dimensional artificial ECM or scaffold to provide structural organization and support for the proliferation and differentiation of cells to create a neo-tissue. It is the interaction of the cells’ with the artificial ECM that is pivotal in recreating and maintaining the functional and 3D Quick Response Code www.idjsr.com
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».