Neuroendocrine tumors (NET) of the gastrointestinal tract: A decade of experience at the Princess Margaret Hospital
Notice bibliographique
Résumé
4093 Background: NET are uncommon malignancies with variable natural history and often indolent biological behavior. Over the past decade novel treatment approaches have been developed. There have been few recent descriptions of large institutional experiences with multi-modality therapy for this disease. Methods: The Princess Margaret Hospital cancer registry identified 207 patients (pts) with NET of the gastrointestinal tract or unknown primary who had their initial visits between 1992 and 2002. A retrospective chart review was performed. Results: The median follow-up duration was 25 months for pts who have died and 54 months for those alive at last follow-up. Demographics of the entire cohort of 207 pts were as follows: M:F = 53%:47%; mean age = 55 years; age-adjusted Charlson score 0 = 71%. Anatomical distribution of the primary location revealed that 33% were from the foregut, 37% from midgut, 13% from hindgut and 17% from unknown origin. Pathological distribution demonstrated that 73% were NET/carcinoids, 21% were islet cell tumors and 6% were small cell carcinomas. One-third of the cohort had biochemically and/or clinically functional tumors, 24% were non-functional, and 43% were not biochemically tested and were clinically non-functional. At presentation, 61% of pts had distant metastases and 39% had locoregional disease. Curative surgery was performed in 38% of the cohort, whereas radiotherapy and chemotherapy of any intent were delivered to 15% and 34% respectively. Octreotide LAR was part of the therapeutic regime in 13% of pts. Two-year survival analysis was evaluated among 114 pts, with the remaining cohort being excluded due to either insufficient follow-up or because pts were seen for second-opinion only. Factors that were significantly related to decreased survival in univariate analyses were the presence of distant metastases and small cell histology. All pts who underwent curative surgery in this subgroup were alive at 2 years, and 88% were alive at 5 years. Conclusions: Pts with NET who are offered curative surgery have a good outcome. Distant metastases are commonly found at presentation and portend a worse prognosis. These patients should be evaluated by a multidisciplinary team regarding new approaches to surgery and other therapies. No significant financial relationships to disclose.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».