Genotoxic effects of pesticide exposure on farmworkers in the Fraser Valley of British Columbia
Notice bibliographique
Résumé
This study measured micronuclei in peripheral blood lymphocytes from British Columbia seasonal farmworkers and controls. The farmworkers were employed to harvest berry crops and were occuparionally exposed to pesticides. In British Columbia, seasonal farmworkers are predominately of East Indian ancestry and the majority are female. Cytogenetic analysis was performed on 39 female subjects of East Indian descent; 18 farmworkers employed during 1993 season and 21 age-matched controls. The mean age was 55.9±9.8 years. An average of 2000 binucleated lymphocytes were scored per individual, and micronuclei were also scored for the presence of kinetochores using CREST anti-bodies. There was no significant difference between the farmworker group (21.68 ± 10.42 micronuclei per 1000 binucleates), and the control group (23.60 ± 10.87 micronuclei per 1000 binucleates). However, among the farmworkers employed during 1993, there was a weak positive association between micronucleated cell frequency and weeks worked: 18.46 ± 8.50 micronuclei per 1000 binucleates in those working less than to 20 weeks to 27.87 ± 15.33 micronuclei per 1000 binucleates in those working more than 23 weeks. In those who had ever been employed as farmworkers, there was an elevated frequency of micronucleated cells in the group with the longest history of employment as a farmworker (26.58 ± 10.53 micronuclei per 1000 binucleates) vs. those with the shortest employment history (17.60 ± 9.04 micronuclei per 1000 binucleates). This trend remained evident after adjusting for age, RBC folate, meat and coffee consumption, recent vaccination, and socioeconomic status. A positive association between the consumption of meat and micronucleus frequency was also noted. Non-meat eaters were likely life-long vegetarians. This study indicates that seasonal farmworkers may have an elevated risk of genetic damage, and steps should be taken to mitigate their exposure to pesticides. Further studies employing more subjects, internal controls and utilizing a larger battery of genotoxicity assays are required. Studies on farm sites also need to be undertaken to develop adequate analyses of farmworker tasks and exposure potential. Use of biological monitoring for pesticide metabolites or exposure modeling using dermal transfer coefficients may provide quantitative exposure data.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».