Hydroxyapatite-coated cardiovascular stents.
Notice bibliographique
Résumé
Description and history Extensive clinical practice supported with evidence gathered during numerous animal studies has shown that in addition to its excellent biocompatibility, hydroxyapatite (HAp, a crystalline derivative of calcium phosphate) is non-toxic and does not induce allergic or inflammatory reactions. The latest research on HAp appears to confirm that HAp crystals “do not acquire a pro-inflammatory or thrombogenic phenotype, but express markers of functioning endothelium that might contribute to angiogenesis.”1 The new generation of non-polymeric drug-eluting cardiovascular stents (as compared to polymer-coated stents) is expected to offer drug delivery solutions which will be less thrombogenic and more tolerable by the body environment (less restenotic) while, at the same time, capable of delivering the desired quantity of drugs in a manner that reflects recommendations of scientists, and responding to the reallife needs and abilities of the patient. These generic observations prompted MIV Therapeutics Inc. to consider HAp as a coating suitable for drug delivery on cardiovascular stents. Such HAp coated stents are being developed within the collaborative research and development program between University of British Columbia, and MIV Therapeutics Inc., both located in Vancouver, BC, Canada. The challenge is that the brittleness of ceramic HAp coating has to withstand deformation during stent crimping and implantation, and remain undamaged and biologically inert years after the implantation into arteries of human heart. In response to this challenge, several novel coating technologies have been developed in 20032005 for deposition of HAp ceramics on stents and other implantable medical devices, by combined efforts and ingenuity of the teams of MIV Therapeutics, Inc. and University of British Columbia. Technical specifications “Wet” chemical technologies were used for deposition of ultra-thin (0.1-0.2 μm) and micro-thin (0.3-1.0 μm) HAp coatings. The ultrathin films composed of high-density non-porous hydroxyapatite are designated primarily as a biocompatible surface modification of metallic implants, whereas the micro-thin films which possess highly porous structure were developed and evaluated also as a potential vehicle for effective and highly engineerable drug delivery. The deposition of the 0.1-0.2 μm ultra-thin films of HAp ceramics used sol-gel (SG) subjected to heat treatment at 450°C which ensured their structural integrity and necessary mechanical properties. The resulting SG-HAp Class “0” ultra-thin “passive” (drug-free) coatings are very well bonded to metal substrates such as stainless steel or Co-Cr alloys, feature acceptably smooth surface (Figure 1) and survive undamaged the stent crimping-implanting-expansion proce-
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».