RECOMMENDATIONS FOR BRADYKINESIA ASSESSMENT IN PARKINSON DISEASE
Notice bibliographique
Résumé
Purpose/Hypothesis: The purpose of this study was to examine whether active flexion and extension at the elbow joint is an effective method of quantifying bradykinesia in PD (Parkinson disease). Bradykinesia is a cardinal symptom of PD that is conventionally assessed at the digits via finger tapping movements. However, when quantifying bradykinesia with finger tapping, it is often confounded by entrainment of tremor. Terefore, we sought to determine whether rapid alternating movement at the elbow joint would provide a more effective measure of bradykinesia in people with PD. We also examined whether bradykinesia measurements were related to upper extremity rigidity measured at the elbow joint. Number of Subjects: Eight subjects with PD were tested on their more involved side and 4 healthy control subjects were tested on their dominant side. Subjects with PD were of medication. Materials/Methods: Subjects were seated comfortably in a chair. To quantify bradykinesia, subjects were instructed to 1) tap their fngers as fast as they could and 2) move through their full elbow range of motion as big and as fast as they could. We recorded total excursion as well as velocity of movements for three ffteen-second trials using a 3-D motion capture system (Motion Analysis Corporation, Santa Rosa, CA). To assess rigidity, the subjects were told to relax their arm as best as they could while the tester passively moved their arm into full flexion and extension. Total impedance was measured with a Rigidity Analyzer (Neurokinetics, Alberta, Canada) and averaged over three fifty-second trials. T-tests were used to compare bradykinesia measurements between groups and a Pearson product moment correlation was performed within the PD group to examine the relationship between bradykinesia and rigidity measures. Results: There was no difference in finger tapping velocity between the groups. There was a significant group difference for elbow velocity between the PD and control groups (p = 0.029). There was also a strong negative correlation (r = −0.805) between elbow joint excursion and rigidity in the PD group. Conclusions: We have demonstrated that repeated active elbow flexion and extension is an effective method of assessing bradykinesia in PD and can reveal deficits that may not be detected using a finger tapping task. We also speculate that rigidity is a contributing factor in hindering movements of the arm in patients with PD. Clinical Relevance: Assessment of bradykinesia may be done proximally at the elbow joint, rather than at the fngers, to eliminate the influence of distal tremor.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».