P1-S6.54 Medical male circumcision may be protective of urogenital<i>Mycoplasma genitalium</i>infection: results from a randomised trial in Kisumu, Kenya
Notice bibliographique
Résumé
Background We determined the prevalence of Mycoplasma genitalium (MG) and whether this was associated with circumcision status, among men enrolled in the randomised trial of medical male circumcision (MMC) to prevent HIV acquisition in Kisumu, Kenya. Methods MG was detected in first void urine (FVU) by APTIMA transcription mediated amplification (TMA) assay. FVU and urethral swabs were assessed for Neissseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) by PCR, and for Trichomonas vaginalis (TV) by culture. HSV-2 detection was by IgG ELISA. Personal interview assessed socio-demographic and behavioural risks. All men underwent standardised medical history and physical examination. Results July through September 2010, 52 (9.9%; 95% CI: 7.3 to 12.4%) MG infections were detected among 526 men. The prevalence of NG (1.4%) and TV (2.7%) did not differ by MG status. CT prevalence was 5.8% among MG-infected men, and 0.8% among MG-uninfected men (p=0.02). CT infection at enrolment was more prevalent among MG infected men (27% vs 9% uninfected, p=0.005); NG and TV at enrolment were not associated with MG. Current urethral discharge symptoms and exam findings did not vary by MG status (1.9% positive vs 1.5% negative, p=0.80), but remote history of urethral discharge (past 6 months) was 5.8% among men with MG vs 2.1% uninfected (p=0.10). The prevalence of MG was 13.4% in uncircumcised men vs 8.2% in circumcised men (p=0.06). In multivariable logistic regression, circumcision status nearly halved the odds of MG [adjusted OR=0.54; 95% CI 0.29 to 0.99], adjusted for variables significant at the p<0.05 level: HSV-2 infection [aOR=2.05; 95% CI 1.05 to 4.00], CT infection at enrolment or at follow-up [aOR=2.69; 95% CI 1.44 to 5.02], washing the penis ≤1 h after sex [aOR=0.47; 95% CI 0.24 to 0.95]. The prevalence of MG did not differ by HIV status, age, education, marital status, number of sex partners, condom use, or sex during menses. There were no interactions with circumcision status. Conclusions Prospective study is needed to verify the potential protective association between MMC and MG. The mechanism by which MMC may protect against MG is unclear. Randomised trials have not found MMC to protect against other urethral infections (NG, CT, TV), though circumcised and uncircumcised men may have different peri-urethral bacteria and penile microbiome. The role of MG in STI morbidity, syndromic management algorithms and antibiotic regimens for men and women in this region should be evaluated.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».