Abstract B127: Family history of breast cancer and risk of contralateral breast cancer
Notice bibliographique
Résumé
Abstract Purpose: Family history of breast cancer increases a woman's risk of developing a first primary breast cancer. A meta-analysis of case-control studies of first primary breast cancer reported an increased risk associated with having an affected first-degree relative (OR=2.1, 95% CI=2.0–2.2), and the risk was even greater when subject and relative were diagnosed before age 50 (OR=3.3, 95% CI=2.8–3.9) (Int J Ca 1997;71:800–9). In this study, we examined family history of breast cancer as a risk factor for developing asynchronous contralateral breast cancer (CBC) and compared these risks to those from the aforementioned meta-analysis. Methods: The Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study is a case-control study including women from five population-based cancer registries: four in the US and one in Denmark. The 708 cases in this study were women with CBC and the 1399 individually matched controls were women with unilateral breast cancer (UBC). All participants were initially diagnosed between January 1985 and December 2000 at age 54 years or younger, and were queried about family history of breast cancer among female first- and second-degree relatives. Multivariable-adjusted rate ratios (RR) and corresponding 95% confidence intervals (CI) were calculated using conditional logistic regression. Results: Compared with women who reported no affected relatives, women with at least one first-degree relative with breast cancer were at increased risk of developing CBC (RR=2.1, 95% CI=1.6–2.7); the risk was greater when more than one relative was affected (RR=2.6, 95% CI=1.5–4.6), and was nearly 4-fold (RR=3.9, 95% CI=2.3–6.4) for women having a relative diagnosed with CBC. The risk of CBC was 3.1 (95% CI=1.8–5.3) when both relative and subject were diagnosed before age 45. When the relative was diagnosed before age 45, regardless of subject age, the risk of CBC was 2.6 (95% CI=1.7–4.1). Similarly, when the subject was diagnosed before age 45, regardless of relative's age, the risk of CBC was 2.5 (95% CI=1.7–3.6). Conclusions: The risk of developing CBC is increased among women with a family history of breast cancer, and this risk is significantly greater among those with an affected relative with bilateral cancer, having more than one affected relative, and having relatives affected at young ages. Our results comparing CBC cases to UBC controls were similar to studies where UBC cases are compared to population controls. Citation Information: Cancer Prev Res 2010;3(1 Suppl):B127.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,010 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,005 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,009 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».