Diverticular disease-associated segemental colitis: A 14 year follow up
Notice bibliographique
Résumé
Diverticular Disease-Associated Segmental Colitis is a variant of chronic colitis which is limited to the rectal area, which is associated with diverticular disease. Histologically it can be differentiated from idiopathic colitis with limited inflammation to the segment and sparing the rest of the colon. There is no long term data on the natural history of this entity. This is a prospective fourteen year follow up on 14 patients who presented with recurrent abdominal pain, with bloody mucousy diarrhoea. Patients were referred either from the emergency room of a teaching hospital or from private offices. Investigation included haematological and biochemical parameters, stool cultures including C. difficile toxin. Colonoscopy with multiple biopsies was performed on all patients at admission and repeated at one year and every three years or earlier. Patients who had acute diverticulitis with CT scan finding of abscess or stricture were excluded. Patients who were diagnosed with acute colitis were excluded. All patients were started on Mesalamine and some received intermittent courses of topical 5ASA therapy. There were 9 males and 5 females with a mean age of 53.2±14.5. The mean duration of symptoms was 34.8± 27 weeks. All patients fit the criteria for Diverticular Disease-Associated Segmental Colitis. Endoscopically the mucosa revealed patchy hyperaemic changes without any evidence of ulceration. This involvement was restricted to the segment with diverticular involvement. Histologically the biopsies showed moderate on chronic colitis with moderate gland distortion, mucin loss and lymphoid hyperplasia. The biopsies proximal and distal to the involved areas were reported to be normal. Five patients stopped their medications and relapsed within six weeks, and were restarted on Mesalamine. The mean follow was 10.4 ± 4.2 years. All patients were treated with Mesalamine at a dose of 1220±600mg. three patients underwent resection for persistence of symptoms and remained asymptomatic. Three patients had intermittent flare ups of symptoms. One patients developed severe diverticulitis and perforated. He subsequently died. Diverticular Disease-Associated Segmental Colitis may respond to 5-aminosalicylate with improvement in symptoms. These patients are at the risk of developing diverticulitis and recurrence in symptoms. Although Mesalamine appears to control the symptoms flare-ups are not uncommon. A proper placebo controlled study is needed to ascertain the natural history of this entity.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; les deux têtes enseignantes s’accordent sur ce qui est montré ici.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».