Abstract 5505: Risk of second malignancies in patients with Chronic Lymphocytic Leukemia: A population based Canadian study
Notice bibliographique
Résumé
Abstract A previous population based study on Chronic Lymphocytic Leukemia (CLL) in Manitoba, Canada, demonstrated that in elderly patients the relative survival is reduced, with the difference being greater in males (Seftel et al. 2009). In this study we evaluated the risk of 2nd cancers in an unselected Canadian CLL population to determine whether 2nd cancers might explain the poor relative survival seen in older men with CLL. All CLL diagnoses in Manitoba (Jan 98-Dec 03) were obtained from the Manitoba provincial cancer registry and a centralized flow cytometry database. All cases were reviewed to confirm the diagnosis of CLL. For each patient, the time at risk was considered from the index cancer diagnosis (CLL diagnosis where CLL is the first primary cancer) to the second primary cancer, date of death or censoring date (Dec 09). The Standardized Incidence Ratio (SIR) was calculated to compare the observed number of second cancers in CLL patients with an expected number derived from age, gender and calendar year specific standardized rates of second malignancies for patients with follicular lymphoma (FL). Of 612 patients, 148 (24%) had a history of a previous cancer and were eliminated from the study. Of the remaining 464 (median age 69 y, F:M ratio 1:1.4) 104 (22.88%) patients eventually developed a second malignancy (median follow up 6.4 y, median time to develop 2nd cancer 3.3 y). CLL patients had a 1.8-fold higher relative risk of a 2nd cancer (95% CI 1.29-2.41) compared to FL patients. SIR was 1.9 when non-melanoma skin cancers were excluded. Patients with FL had a similar incidence of second malignancies, as did patients with other invasive cancers. The most common second cancer among CLL patients was non-melanoma skin cancer, followed by cancers of the digestive organs, prostate, breast and lung. Malignancy was the leading cause of death in CLL patients. In patients with a 2nd cancer, cancers of the digestive organs, lung and brain were the most common causes of death. However, in patients without a 2nd cancer, CLL was the primary cause of death. After cancer, cardiovascular complications and infections were the most common causes of death in CLL patients. This study is unique in that (a) it is a population-based study of CLL patients with a confirmed diagnosis (b) the risk of 2nd cancers was compared with another cancer cohort. FL is an indolent B cell neoplasm that is treated and followed in similar ways to CLL. We demonstrated that CLL patients have a significantly increased risk of developing a 2nd cancer compared to FL patients, and this increase was similar in both genders and in all age groups. Thus, the poor relative survival of older men with CLL cannot be explained by an increased incidence of 2nd cancers. The increased incidence of malignancy in CLL may be related to the immune suppression in this disease or to an inherited predisposition to cancer. Further investigations are underway to better explain our observations. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5505. doi:1538-7445.AM2012-5505
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,003 |
| Études des sciences et des technologies | 0,002 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».