Corpus Callosum Atrophy in a Patient with Neuromyelitis Optica
Notice bibliographique
Résumé
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system characterized by recurrent episodes of optic neuritis and transverse myelitis 1 .The most prominent magnetic resonance image (MRI) finding in NMO is longitudinally extensive transverse myelitis.We report a woman with corpus callosum atrophy on brain MRI, who was initially diagnosed as having multiple sclerosis (MS). CASE REPORTThis otherwise healthy Caucasian woman had presented at the age of 20 with left optic neuritis, which had resulted in complete loss of vision in this eye, followed by several episodes of transverse myelitis and contralateral optic neuritis, with partial recovery.One year later, she was diagnosed with MS, and treated with varying doses of oral prednisone and azathioprine.She continued to have repeated episodes of optic neuritis and transverse myelitis.Five years since onset, interferon beta1-b 250 mcg SC qod was started in combination with azathioprine.She had no further neurologic episodes over the following year, until azathioprine was discontinued due to neutropenia, and interferon beta1-b was continued at half dose.Subsequently, she had recurrent episodes of optic neuritis and transverse myelitis, treated with high dose steroids at least twice a year.Eight years after presentation, interferon beta1-b was discontinued, and she started glatiramer acetate 20 mg qd.She continued to experience optic neuritis at least twice a year, treated with high dose steroids.When she presented to us 18 years after initial presentation, her best visual acuity was finger counting at three meters on the right, and no light perception on the left.Pupils were dilated and unreactive to light on the left, with a sluggish response to light on the right.She had left exophoria and nystagmus in all directions of gaze.She had a spastic quadriparesis, and was able to take a few steps with a walker.Laboratory investigations revealed weakly positive ANA, elevated rheumatoid factor of 158 IU/mL, negative anti-dsDNA, negative anti-ENA screen, normal vitamin B12 levels.Serum NMO antibody was reported positive by Mayo Clinic laboratory in Rochester Minnesota, USA.Brain MRI showed callosal atrophy, centrally in the body.A few nonspecific high T2 signal white matter abnormalities were seen in the deep white matter of the hemispheres.No lesions were seen in the posterior fossa or the periventricular areas.The spinal cord was markedly atrophic, and no signal change was seen in the spinal cord.No abnormal enhancement was seen with Gadolinium (Gd) injection.(Figure ) We recommended discontinuation of glatiramer actete; azathioprine was initiated.At the time of preparation of this
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,003 | 0,002 |
| Études des sciences et des technologies | 0,004 | 0,002 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,005 | 0,003 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».