Effect of glutamine on doxorubicin-induced cardiotoxicity: an echocardiographic assessment.
Notice bibliographique
Résumé
Abstract Abstract #6143 Background: Doxorubicin (DOX) is a widely used chemotherapeutic agent with a dose-dependent cardiotoxicity. Previous studies showed that dietary glutamine (GLN) reduced cardiac oxidative damages in rats treated with DOX through the increase of cardiac and blood glutathione, reduction of cardiac lipid peroxidation and reducing cardiac apoptosis. The present study aimed to examine further the effect of GLN on DOX-induced cardiac injury and to gain insight into the physiological aspects of this process by using high-resolution micro-ultrasound imaging and Doppler echocardiography. Materials and Methods: Female Fisher 344 rats (n=12) were randomized into 2 groups: (i) GLN-supplemented (n=6) and ii) controls (n=6). GLN-supplemented rats received 1g/kg/day GLN via gavage starting 1 week before DOX administration. DOX (12 mg/kg) was injected i.p. in all animals. Each animal was examined before DOX administration, 3 days, 7 days, and 10 days after DOX administration using ultrasound imaging system Vevo 770 (VisualSonics, Toronto, ON, Canada). RMVTM 716 "high frame" scan head, designed for real-time small animal imaging applications, was used. The short-axis imaging was taken in B-mode to view the left ventricle (LV) movement during diastole and systole. Anatomical M-mode was used to obtain LV measurements including LV end-diastolic and systolic inner diameters, LV posterior wall, LV ejection fraction (%EF) and LV fraction shortening (%FS). The LV filling was evaluated by pulsed-Doppler sampling of the mitral valve (MV) inflow. The peak E-wave velocity (E), peak A-wave velocity (A) and the MV E/A ratio were obtained. All data and images were saved and analyzed by Vevo 770 Analytic Software (VisualSonics, Toronto, ON, Canada). Results: Ten days after DOX treatment the control animals had: i) increased LV posterior wall end-diastolic thickness of an average from 1.7 mm before DOX administration to 1.8 mm and end-systolic from 2.9 mm to 3.7 mm; ii) reduction of the %EF by 10% and %FS by 14%; and iii) increased MVE by 30% with a resulting MVE/A ratio >2.0; all these suggestive of the development of restrictive cardiomyopathy (RCM). RCM, characterized by thickening and increased rigidity of the endocardium due to infiltration and fibrosis, restrictive ventricular filling with MVE/A >2.0 and in some cases reduction of the EF, has been reported in several clinical studies of patients treated with DOX. In GLN-supplemented rats of this study there was no statistically significant difference between posterior wall thickness before and after DOX administration, MVE/A ratio was maintained between 1.4 and 1.8; and EF was reduced by 2% only. Conclusions: The results from this study are in agreement with our previous data showing that GLN is able to reduce cardiac oxidative damages caused by DOX. This data further confirmed the safety of GLN supplementation and its cardioprotective effects during chemotherapeutic treatment with DOX. Acknowledgements: This work was supported by a grant from Susan G. Komen to VKT. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6143.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».