Abstract 1821: International Study of Embryonal Tumors
Notice bibliographique
Résumé
Abstract Background The International Study on Embryonal Tumours (ISET) was initiated by epidemiologists and pediatric clinicians in 13 countries worldwide including 7 in Europe (UK, the Netherlands, Italy France, Serbia, Macedonia, Czech Republic), 3 in America (California USA, Canada, Brazil), and 3 in Asia / Oceania (India, Japan, and Australia), in collaboration with the International Agency for Research on Cancer. The study is focused on the etiology of non-CNS embryonal tumors which have been severely under-studied to date. Due to their rarity, past studies of these tumors have been underpowered and an international effort is required to accrue sufficient numbers of cases. The full study will include retinoblastoma, Wilms tumor, rhabdomyosarcoma, neuroblastoma and hepatoblastoma. Our main objective is to conduct a comprehensive study to investigate the effect of perinatal factors, molecular profiles and gene-environment interaction on the risk of these tumors. Methods This study is based on a case-control trio design, which has been shown to be a powerful design for genetic association and it is robust against the bias due to population stratification. For childhood cancer, the parent-child trio design is particularly appropriate as it can be used to study maternal-fetal effects and parent of origin such as imprinting. We collect information on parental environmental exposure history, medical and family history, as well as data on neonatal and infancy history of the index child by detailed interview with a standardized questionnaire. We obtain DNA samples from the trios. Tumor samples will also be collected in collaboration with clinical trials groups for disease characterization. We plan to investigate the effect of perinatal factors and incorporate molecular profiles of the trios such as epigenetic aberration, germline variation and DNA repair capacity, to conduct comprehensive investigations on gene-environment interactions. Results The pilot study of Wilms tumor and neuroblastoma has been launched in Australia, France, Czech Republic, Serbia, Macedonia and Canada in 2009 and 2010. The estimated number of patients to be recruited varies by study center and cancer site, with a total of approximately 1400 per year (including 640 Wilms tumor and 400 neuroblastoma). The participation rate for case trios is between 70-80%, and among the participating families, more than 95% are willing to provide biological samples. The results of the pilot study will be presented. The pilot results also indicate that the adjustment of study protocol and questionnaire to local requirement is necessary for multicenter study at international scale. Discussion ISET Investigators aim to improve the understanding of etiology and pathogenesis of these tumors, providing new tools for their prevention and control. Greater understanding of factors leading to the development of these tumors may improve surveillance, diagnosis, prognosis, and treatment of these childhood malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1821.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,002 | 0,005 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,008 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».