Notice bibliographique
Résumé
A study of HIV-infected adolescents in Montreal, Canada, has found that more than two-thirds of the young people were failing treatment when they transferred from pediatric to adult healthcare. The findings, which are consistent with earlier reports from the United Kingdom, Ireland and France, indicate that young HIV patients face serious issues with respect to drug resistance and immunodeficiency in their future therapeutic options. Researchers, led by Valérie Lamarre of Université de Montréal, examined medical records of 45 teenagers who segued to adult care between June 1999 and May 2011. Their average age at the time of transfer was 18.1 years, and most of the patients acquired HIV from their mothers. All but two of the young were treated with antiretroviral therapy, but 32 of them were initially exposed to monotherapy or bitherapy before combined antiretroviral therapy (cART) became available. Eleven patients received cART from the start. When they switched to adult healthcare, 26 of the 45 teenagers had detectable viremia. Thirteen, all of whom were first treated with monotherapy or bitherapy, had CD4 T-cell counts less than 200 cells/μl. Of 38 children who had undergone genotypic drug-resistance testing, 28 were resistant to at least one antiretroviral drug, and 12 patients were resistant to at least one drug in each of the major classes of antiretroviral agents. ‘That monotherapy and bitherapy treated patients from early in the epidemic fared poorly compared with adolescents who received only cART was no surprise,’ Lamarre says. However, although cART works very well on adolescents, compliance is a major issue. ‘The problem is getting them to take (the drugs),’ Lamarre says. ‘Furthermore, despite being from the cART era, many of our current adolescents already harbor resistance to non-nucleoside reverse-transcriptase inhibitors from difficulties with taking medication when they were young children, thus, taking away the only current option of an easy-to-take, once-a-day regimen.’ Source: Van der Linden D, Lapointe N, Kakkar F, Ransy DG, Motorina A, Maurice F, et al.The young and the resistant: HIV-infected adolescents at the time of transfer to adult care.J Ped Infect Dis 2012 doi: 10.1093/jpids/pis106 First published online: 19 December 2012. Acknowledgements Conflicts of interest There are no conflicts of interest.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,009 | 0,003 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; les deux têtes enseignantes s’accordent sur ce qui est montré ici.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».