Solid State Hyaluronic Acid Threads
Notice bibliographique
Résumé
INTRODUCTION: Dermal fillers are effective for temporary volume augmentation, especially for deep features like NLFs. This is due to volume expansion, with relatively little precision in placement. Neurotoxins are effective at treating rhytids, but can have undesirable effects on facial expression. Available fillers and neurotoxins are not always optimal for treating fine or long, linear wrinkles, such as necklace lines, transverse forehead wrinkles, and lip contouring. To address these clinical needs, a novel hyaluronic acid (HA) product has been developed which is comprised of a dehydrated, solid HA thread attached to a 27 gauge straight needle. The HA thread is implanted by being pulled into position by the needle, whereupon the thread hydrates and slowly reverts back to a gel. METHODS: A first-in-human prospective multi-center study was conducted in Canada. The primary endpoint was safety, and the secondary endpoints were aesthetic result as assessed by the Investigator, Independent Reviewer, and subject. Photographic documentation was captured by CanfieldScientific. NLFs were rated by a Wrinkle Severity Scale and any other area was rated by a Global Aesthetic Improvement Scale. Subjects received bilateral treatment in one area; NLF, forehead, perioral (including vermillion boarder), necklace lines or crow’s feet. One retreatment was allowed at the 2-week follow-up. Follow-ups were at 1, 3 and 6 months. RESULTS: 72 patients were enrolled and completed this study. At least 10 were enrolled in each of the 5 treatment areas. There were no severe or unanticipated adverse events. Overall, the adverse event rates were comparable or better than published rates for HA dermal fillers. Almost all subjects demonstrated improved aesthetic outcomes despite conservative implantation methods initially. Many subjects demonstrated aesthetic improvement between the 1 and 3month follow-ups. CONCLUSION: The results from this clinical study demonstrate that HA threads are safe, and can be effective in treating difficult areas such as necklace lines, horizontal forehead lines, vermillion boarders, as well as more common areas such as NLFs and crow’s feet. The product lends itself well to features that are linear in nature, whether fine or deep. HA threads are a highly novel, differentiated product that complements injectable fillers and neurotoxins for minimally invasive facial rejuvenation.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,006 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».