Abstract LB-460: Effects of folic acid supplementation on mammary tumor progression
Notice bibliographique
Résumé
Abstract Background: The role of folate in breast cancer is highly controversial. Although some epidemiologic studies have suggested a protective effect of high folate status on breast cancer risk, recent studies have suggested that high folate intake, largely from folic acid (the synthetic form of folate), and high plasma folate levels may increase breast cancer risk. In animal studies, folic acid supplementation was shown to promote the progression of established preneoplastic lesions of colon cancer. Folic acid intake in North America has drastically increased over the past decade due to folic acid fortification and widespread supplemental use. Almost 70% of breast cancer patients consume folic acid containing vitamin supplements after diagnosis. The benefits of folic acid supplementation in patients with breast cancer are unknown and there is a concern that folic acid supplementation may in fact adversely affect breast cancer progression. We therefore investigated the effects of folic acid supplementation on the progression of established mammary tumors in the DMBA rat model. Methods: Female Sprague Dawley rats were placed on a control diet containing 2 mg folic acid/kg diet and mammary tumors were initiated with DMBA at 7 weeks of age. When the sentinel tumor reached a diameter between 7–9 mm, rats were randomized to receive a diet containing 2 (control), 5, 8, or 10 mg of folic acid/kg diet for up to 12 weeks. Body weight and mammary tumor growth were measured weekly and plasma folate levels at necropsy were determined. At necropsy, the sentinel and all other mammary tumors were excised and histologically analyzed. Results: The final weight of the animals at necropsy was not significantly different among the 4 groups. Animals on the control and 10 mg folic acid/kg diet had significantly faster weight gain than those on the 8 mg folic acid/kg diet (p<0.02) while those on the 5 mg folic acid diet did not differ significantly from either group. Plasma folate levels significantly reflected the supplemental levels of folic acid in a dose-responsive manner (p<0.05). Sentinel tumor growth (mm2/week) was not significantly different among the 4 groups at 4, 7, and 12 post randomization. Sentinel tumor weight at necropsy was lower in the control group compared with the 5 and 8 (p<0.05) and with the 10 (p=0.051) mg folic acid/kg diet groups. Total weight of all mammary tumors was highest in 5 and 8 mg supplemented groups compared to the control group (p< 0.05, p=0.086). Conclusion: Our data suggest that folic acid supplementation may promote the progression of established mammary tumors, although no clear dose-responsive relationship was observed. Given the drastically increased folic acid intake and the mortality and morbidity of breast cancer in North America, the potential adverse effect of folic acid supplementation on breast cancer progression needs to be clarified. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-460. doi:10.1158/1538-7445.AM2011-LB-460
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».