P-043 YI Phenotypic Differences in Obese Patients With Crohn’s Disease
Notice bibliographique
Résumé
Crohn’s disease (CD) is a chronic inflammatory condition associated with nutritional risk secondary to decreased oral intake, hypermetabolism and reduced absorption. Conversely, the incidence of obesity worldwide is increasing and the effect of obesity on patients with CD is unknown. We aim to identify traits related to obesity in a cohort of patients with CD. This is a retrospective chart review of 209 consecutive adult patients with confirmed CD seen in our clinic from July 2011 to June 2013. Age, Montreal disease classification, sex, race, duration of disease, Harvey Bradshaw Index (HBI), Short Inflammatory Bowel Disease Questionnaire (SIBDQ) scores, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, physician global assessment, endoscopic appearance, histologic activity, medication use, and body mass index (BMI) data were collected about each patient. One-way ANOVA, Chi-square test and Logistic Regression were used to analyze the data. The mean age was 43.4 ± 14.9 years; 68.9% were Caucasian, and 51.7% were male. The mean duration of disease was 11.0 ± 10.6 years. The mean BMI was 26.8 ± 5.7: underweight (BMI < 20) 7.7%; normal weight (BMI 20–24) 29.3%; overweight (BMI > 25) 38.0%; and obese (BMI > 30) 25%. There were no significant differences among the BMI groups in race (P = 0.228) or gender (P = 0.441). Patients with ileocolonic disease were less likely to be obese or overweight than those with isolated ileal or isolated colonic disease (55.5% versus 68.6% or 75%, P = 0.021). Patients with higher BMI were more likely to have extra-intestinal manifestations (EIM) (underweight 6.3%, normal weight 9.8%, overweight 20%, obese 34.6%, P = 0.005). Patients with non-arthralgia EIMs had a higher BMI than those without such EIMs (29.9 ± 7.2 versus 26.4 ± 5.3, P = 0.004). There was a linear trend with rising BMI and non-arthralgia EIMs (underweight 6.3%, normal weight 3.3%, overweight 13.8%, obese 19.2%, P = 0.010). There was no correlation between duration of disease and BMI (P = 0.670). There was no significant difference in BMI between patients with inflammatory, fibrostenotic or penetrating disease (P = 0.951). There was a linear association between proximal CD and decreasing BMI (underweight 31.3%, normal weight 14.8%, overweight 15.0%, obese 7.7%; P = 0.046). There was no difference in BMI between patients with and without perianal disease (P = 0.216). The majority of patients in our cohort were overweight or obese, which correlates with national trends. Our data demonstrates that extensive disease location—but not disease behavior, duration, or activity—plays a role in weight modulation in CD patients. The linear association with low BMI and upper-tract disease modifier is most likely due to decreased oral intake in these patients due to post prandial pain or early satiety. Increased EIMs in patients with high BMI (even after adjusting for arthralgias, which are common in obese patients) suggests that the chronic inflammation associated with obesity may play a role in extraintestinal inflammation.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».