Does Measuring Infliximab and Human Anti-Chimeric Antibody Concentrations in Patients With Inflammatory Bowel Disease Impact Clinical Management? A Canadian Experience.
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Résumé
Background: Infliximab (IFX) is a chimeric (mouse/human) anti-tumor necrosis factor alpha (anti-TNFa) therapy used for treatment of inflammatory bowel disease (IBD). The main phenotypes of IBD are Crohn's disease (CD) and Ulcerative colitis (UC). On biological therapy, patients may become unresponsive to therapy or develop side effects. The reasons for which may be sub-therapeutic drug levels or development of Human Anti-Chimeric Antibodies (HACA). Objective assessment of these two parameters would help guide therapy in some complex patients with IBD. An HACA serum assay is commercially available through Prometheus Laboratories, Inc., San Diego, CA. In Canada, the Ministry of Health and Long Term Care in Ontario (MOHLT) has granted approval for this test, in selected IBD patients, 12 months ago. Methods: We conducted a retrospective chart review of adult patients with IBD in whom HACA and Infliximab trough levels were estimated, to determine whether these results impacted clinical management. The indications for these tests were recorded for each patient. Approval was sought from MOHLT for performing the test. Serum was collected 24 to 48 hours prior to the next infliximab infusion. Results: Thirty-six patients with IBD (29 CD, 7 UC) had HACA and Infliximab levels estimated. The mean age (SD) was 32.5 (13) years and 56% were females. The mean disease duration (SD) was 10(6) years and mean duration on infliximab therapy (SD) was 4(3) years. Indication for testing were diminished response to therapy in 80%, development of side effects in 14% and primary non-response in 6%. HACA was positive in 7 patients and infliximab levels were undetectable in 9 patients. Infliximab levels were undetectable in all patients who were HACA positive except one. Based on these results, treatment was altered in 78% of the patients. Among the 7 HACA positive patients, 3 were switched biological therapy, 2 were switched to immunomodulators (endoscopy showed inactive disease), 2 were continued on infliximab with increased frequency. Among 29 patients who were HACA negative, 9 patients had undetectable drug concentration. In them, frequency of infusion was increased in 6, dose was increased in 2 (10 mg/kg every 4 weeks), and one patient was switched to another biological agent. After modifications in therapy, the drug levels were retested in 4 patients. It was detectable in 3 and undetectable in one who was then referred for surgery. Among the remaining 20 patients with detectable drug levels (>6.25 lg/mL), only limited modifications were required. Of these, 8 were continued on the same treatment, 6 were switched to another biological agent, the infliximab dose was increased in 3, started immunomodulator therapy in 2 and in one patient the dose of infliximab was decreased. Conclusion: Measurement of HACA and infliximab concentration impacts clinical management of patients with IBD. The use of these tests helps tailor therapy and optimizes patient management.
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Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle