Effect of zinc supplementation on mental development and motor development in infants:a meta-analysis
Notice bibliographique
Résumé
Objective To assess the efficacy of zinc supplementation for improving psychomotor developmental and mental developmental outcomes in infants younger than 3 years.Methods According to the requirements of Cochrane systematic review,a literature search was performed among PubMed,EMBASE,Cochrane library,CNKI,VIP and Wanfang data from the establishment of the database till October 2010. Mental developmental index (MDI),psychomotor developmental index (PDI) and development quotient (DQ) of 6-36 months after birth were measured as therapeutic efficacy index.RevMan 5.0 software was used for meta-analysis. The Cochrane handbook 5.0.2 was used to evaluate the methodological quality. Data extraction,quality assessment,and meta-analysis for the results of homogeneous studies were performed by two reviewers. Heterogeneity of the included articles was tested to select proper effective model. Measurement data were expressed as SMD,WMD and its 95%CI.Results Eighty-four articles were searched according to the inclusion and exclusion criteria,21 reviews,37 studies without zinc supplementation,5 studies for pregnant mothers,5 studies for children older than 3 years,1 study in which zinc supplementation was not the only different intervention compared with control group and 5 studies without the outcomes were excluded. Ten RCTs meeting the inclusion criteria were enrolled. The assessment of literature quality showed 7 literatures described the method of random allocation in detail,8 literatures described allocation concealment,8 literatures used double blind method,9 literatures reported complete data addressed and 9 literatures were free of selectively reporting. Only 1 literature described the sources of other bias.There was clinical heterogeneity in the 10 included studies. Nine RCTs (n=2 250) reported PDI with the Bayley Scales of Infant Development or Griffiths Mental Development Scales. There was no significant difference in the PDI between two groups,SMD=0.15(95%CI:-0.12 to 0.42). Eight RCTs (n=2 136) reported MDI with the Bayley Scales of Infant Development. There was no significant difference in the MDI between two groups,WMD=-0.08(95%CI:-1.55 to 1.40). Subgroup analyses were carried out for dosage,formulation (zinc alone or zinc combined with other nutrients) and nutrition status (varying measles case fatality rates). None of these subgroup analyses showed significant difference in the MDI or PDI between groups. One RCT (n=114) reported DQ using the Griffiths Mental Development Scales. The WMD of DQ was-0.72 (95%CI:-7.97 to 6.53). Another RCT (n=70) reported the change in Alberta Infant Motor Scale and did not show significant difference between groups,WMD=0.30(95%CI:-2.09 to 2.69).Conclusions Supplementation of zinc shows no effect on psychomotor development and mental development in infants. Further studies are needed to determine whether the findings are reproducible.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,002 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».