Abstract 1434: Diabetic metastatic castration-resistant prostate cancer patients administered metformin during docetaxel chemotherapy have improved prostate cancer-specific and overall survival
Notice bibliographique
Résumé
Abstract Introduction and Objective: Docetaxel (DTX) chemotherapy is currently one of the only treatment options for patients with metastatic castration-resistant prostate cancer (mCRPC). Although DTX treatment has been shown to provide survival benefits, it is not curative. Thus, there is a continued need to improve the therapeutic options available for mCRPC patients. One approach is combining DTX with other agents that enhance its effectiveness (i.e. chemosensitizers). Metformin, a commonly prescribed and well-tolerated oral biguanide used to treat type II diabetes, has been shown to exert anti-neoplastic effects in several types of solid tumors, including prostate cancer. More specifically, metformin has been shown to improve the efficacy of chemotherapy in breast cancer and colon cancer models. Niraula et al (2013) evaluated the effect of metformin combined with DTX in prostate cancer patients who participated in the TAX 327 trial. Metformin did not have a statistically significant additive or synergistic effect with docetaxel, but only 38 patients were included in the analysis. There is very limited data examining the combined effect of metformin and DTX in prostate cancer patients. Therefore, the objective of this study is to determine if diabetic mCRPC patients administered metformin during DTX treatment have improved prostate cancer-specific (PCa-specific) and overall survival (OS) when compared to nondiabetic mCRPC patients receiving DTX therapy. Methods: The primary objective of this retrospective study is to analyze patient data from the Ontario Cancer Registry (OCR), Ontario Diabetes Database (ODD), Canadian Institute for Health Information Discharge Abstract Database (CIHI DAD), National Ambulatory Care Reporting System (NACRS), Ontario Health Insurance Plan (OHIP), and the Registered Persons Database (RPDB) evaluate whether there is a difference in PCa-specific and OS between diabetic mCRPC patients administered metformin during DTX treatment and non-diabetic mCRPC patients receiving DTX treatment. The databases described previously are all accessible through the Institute for Clinical Evaluative Sciences (ICES) in Ontario, Canada. Data has been collected and linked at ICES and a research-ready, anonymized dataset has been provided to our research group. Since receiving access to the dataset from ICES, statistical analysis (including multivariate Cox proportional hazards regression, logrank test, and Kaplan Meier survival curves) is in progress using SAS software. Results and Conclusions: Data analysis is currently in progress. If metformin is shown to have a chemosensitizing effect in diabetic mCRPC patients, this would indicate a novel therapeutic approach that is needed for this patient population. Citation Format: Michelle Mayer, Laurence Klotz, Vasundara Venkateswaran. Diabetic metastatic castration-resistant prostate cancer patients administered metformin during docetaxel chemotherapy have improved prostate cancer-specific and overall survival. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1434.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».