F-073THE EFFECT OF COLCHICINE ADMINISTRATION ON POSTOPERATIVE PLEURAL EFFUSION FOLLOWING THORACIC SURGERY: A RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED, FEASIBILITY PILOT STUDY

Objectives: Colchicine was previously found to be effective in preventing postoperative pericardial effusion following cardiac surgery with potent anti-inflammatory effects. This study seeks to assess its effect on the volume of postoperative pleural drainage, duration of chest tube in-situ and length of stay following lung resection. Methods: Between April 2014 and April 2015, 100 patients undergoing lung resection at two tertiary care centres were randomized to either colchicine (n = 49) or placebo (n = 51) treatment arms), as part of a feasibility, pilot double-blind study assessing colchicine for prevention of perioperative atrial fibrillation. Patients received either colchicine 0.6 mg or placebo orally twice daily for 10 days, with the first dose given 4 hours prior to surgery. Pleural drainage volumes were recorded in 8-hour intervals until chest tube removal as per a standardized, pre-defined protocol. Results: The two groups were comparable on baseline characteristics with regard to cancer stage, comorbidities, surgical approach and extent of resection (51% open procedures; 86% anatomic resections), but not for gender, coronary artery disease and hypertension. Analysis of total drainage volumes demonstrated a statistically significant difference in favour of the colchicine group (583.8 vs 763.3 ml, P = 0.039), with findings that remained consistent across the time intervals collected. The volume of pleural drainage at 1-hour postop was significantly less in the colchicine group (92.9 vs 156.6 ml, P = 0.008), and remained lower at the 40-hour interval (550.9 vs 741.3 ml, P = 0.039). There were no differences in time to chest tube removal (6.8 vs 5.9 days, P = 0.585), hospital length of stay (7.4 vs 6.9 days, P = 0.641), or with regards to major bleeding, infection or adverse events. Conclusion: Perioperative administration of oral colchicine is potentially effective in diminishing the amount of pleural drainage post-lung resection. A full-scale, prospective placebo-control randomized trial is needed to assess the clinical significance of perioperative colchicine administration. Disclosure: A. Bessissow, J. Agzarian, S. Srinathan, L. Schneider, P. Devereaux, J. Neary W. Dechert, L, Gandy, C. finley, W.C. Hanna. C. Schieman and Y. Shargal: Colchicine, prepared by Bay Area Research Laboratory. P. Devereaux: Research grants: Canadian Institute of Health Research Open Operating Grant; Physicians Services Incorporated Foundation Research Grant, J. Neary: Research grants: Physicians Services Incorporated Foundation Research Grant.

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.