The Effect of Neuronal Growth Factor on the Early Recovery After Experimental Sciatic Nerve Defect in Rabbits
Notice bibliographique
Résumé
Objective/Hypothesis: The facilitation of early functional recovery after peripheral nerve damage is a key component in the treatment of severe nerve traumas. The regeneration of peripheral nerves is determined by multiple factors. The nerve growth factor (NGF) plays an important role in the recovery process by facilitating the Schwann cell proliferation and helping to prepare the reception of the regenerating axon. The purpose of the study was to evaluate the rate of early nerve regeneration in the presence or absence of NGF treatment, using either silicon tubes or autolog veins as a bridge for the neuron defect in a rabbit model of nerve injury. Materials and Methods: White Canadian rabbits were used in the study. Animals were divided into 4 groups (n = 10 in each group). Under general anesthesia, 1 cm long part of the sciatic nerve was removed and the ends were connected with either silicon tube or autolog vein. In case of 10-10 rabbits, NGF was added into the connecting tubes or veins. For another 10-10 rabbits (Control animals), only plasma was added. Electrophysiological examination was performed 2, 4, 6, and 8 weeks following surgery. Histological examination was done on the postoperative second, fourth, and sixth week on 2-2 animals and on the postoperative eighth week on 4-4 animals. Results: The regeneration analyzes demonstrated that the NGF-treated nerves had already become more mature and organized by the postoperative fourth week. The rest of the fibers were still demyelinated; however, there were more myelinated fibers in the NGF-treated group. On the sixth week, the regenerated parts formed into small fascicules, showing a diffuse pattern of myelinated and demyelinated fibers. On the eighth week, the fascicules were strengthened with the signs of longitudinal vascularization. We found significantly higher number of myelinated fibers in the NGF containing tubes, compared with the Controls. Conclusion: Here, we demonstrated that the NGF-treated regenerating nerves show more maturity and neuronal organization on the fourth and sixth week, compared with the Control groups. This effect could facilitate the early functional recovery after peripheral nerve injuries. While NGF has a significant effect on the early regeneration of the rabbit sciatic nerve, based on our results, the endogen NGF has no significant effect on the late nerve regeneration process.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».