DETERMINATION OF INDICATORS OF EPILEPTIC SEIZURE EVENTS ON THE SEIZURE MONITORING UNIT AND THE DEVELOPMENT OF AN ELECTRONIC DATABASE
Notice bibliographique
Résumé
INTRODUCTION Epilepsy is a neurological disorder characterized by recurrent seizures and affects approximately 1% of Canadians. While treatment with medications is often effective, 40% of the 300 000 Canadians suffering from epilepsy are refractory to medications. Furthermore, only 5% of patients with refractory epilepsy respond clinically to additional antiepileptic drug (AED). This group of patients is referred to the Calgary Epilepsy Program (CEP). To clarify diagnoses, optimize therapy or for pre-surgical evaluation, they are subsequently admitted to the Seizure Monitoring Unit (SMU) for on average 8 days. However, over a fifth (21%) of SMU patients do not have seizure events while on the unit. The purpose of this study was first to develop an electronic database for SMU patients and then to utilize patient data to predict the likelihood of their seizure events on the SMU. METHODS SMU Admission/Discharge summary forms were created in REDCap, an electronic survey builder. Assessed variables include: demographics, reason for referral, seizure frequency and type, type of medications, procedures performed and tests ordered. Multiple quality of life and depression scales, including: AEP, Bacca Scale, EQ-5D-3L, GADS, GASE, NDDI-E, PANAS, PHQ-9, QOLIE-31 and TSQM-II were added for future data collection. Patient admission data (n=603) from 2008 to 2014 was analyzed using chi-squared test and Student’s t-test. Patient characteristics, including: age, number of AEDs, seizure frequency and psychotropic medications before admission were compared between those that had seizure events and those that did not have seizure events on the unit. Data was analyzed on iPython Notebook. RESULTS Patients with seizure events (n=474) had more AEDs (1.9 ± 1.1 vs 1.6 ± 1.1, p < 0.01), a higher seizure frequency (Daily vs Weekly, p < 0.05) or were less likely to be on psychotropic medications (26.5% vs 44.5%, p < 0.001) before admission. There is no statistically significant correlation between age and the occurrence of seizure events. DISCUSSION AND CONCLUSIONS CEP and SMU patient data can now be accessed through a single electronic database to facilitate epilepsy research and patient care. The database linking patient admission data to measurements of patient quality of life, depression and satisfaction will give researchers better insight into treatment outcomes for patients with epilepsy. The probability of having a seizure event on the SMU is higher with a higher number of antiepileptic drugs (p < 0.01), higher seizure frequency (p < 0.05) or lower number of psychotropic medications (p < 0.001) before admission. The use of pre-admission variables to predict the likelihood of seizure events on the SMU will help improve referral accuracy and reduce unnecessary hospitalization which costs several thousand dollars daily. Continued analysis of other variables includes seizure type, primary reason for referral, type of AED and type of psychotropic medication.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,006 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».