Investigations on age and breed-associated differences in energy intake, growth rate, body composition, haematological and biochemical values of Labrador Retrievers and Miniature Schnauzers fed different dietary levels of vitamin A
Notice bibliographique
Résumé
Balanced nutrition ensuring adequate intakes of energy, protein, minerals and vitamins is essential for the optimal development of young dogs. An adequate energy supply of growing dogs is critical in controlling the growth rate. Research in rodents indicates that dietary vitamin A impacts energy utilisation; the potential impact on the energy metabolism in dogs and consequently on the energy intake, body composition and growth velocity in growing dogs however remains unclear. The literature survey in Chapter 2 indicates that the definition of healthy growth is difficult and controversial. The assessment of ideal body condition of growing dogs is more difficult compared to adult animals because increased energy intake results in increased growth rate, but not necessarily in increased body fat mass. Guidance values for energy intake and body weight development do exist, however considerable variability can be observed between breeds. The overview of studies investigating breed and age related changes in haematological and blood chemical values during growth clearly shows that prominent changes occur. Therefore results obtained from puppies have to be interpreted with care to correctly assess the health status as values may deviate from values found in adult dogs. Chapter 3 explains the main aims and hypotheses of this thesis. The main work of the current thesis consists of two published manuscripts summarized in Chapter 4 and 5. In the first manuscript the possible effects of different dietary vitamin A concentrations on energy intake, growth rate and body composition in Labrador Retriever and Miniature Schnauzer puppies have been evaluated. However, based on the well-documented high tolerance of dogs to dietary vitamin A levels up to 104.8 μmol retinol (100 000 IU vitamin)/4184 kJ (1000 kcal) it was hypothesized that energy intake and accumulation of body fat would be unaffected (Chapter 4). This was confirmed by the results of our study. Given the findings of Morris et al (2012), vitamin A was not considered as a factor in the evaluation of the haematological and biochemical data in the second manuscript (Chapter 5). The main interest of the second manuscript was to increase the knowledge on breed, sex and age effects and their interaction during the first year of life. The evaluation shows that age and breed-related changes in haematological and blood chemical test results are evident in young Labrador Retriever and Miniature Schnauzer dogs. The results confirm the need for age-specific reference ranges for the interpretation of clinical data obtained from young puppies. The potential effects of dietary vitamin A as well as growth related alterations in body tissue and metabolism are discussed in Chapter 6 together with the results obtained from this study. In conclusion, the results of the current study suggest that unlike to rodents dietary vitamin A does not affect energy utilization, growth rate or body composition in dogs. The underlying biochemical mechanisms however remain unclear and require further clarification. With regards to haematological and blood chemical parameters the study showed marked age and breed related changes illustrating growth related alterations in body tissue and metabolism during the first year of life. The early growth phase clearly appears to be most critical and needs to be investigated in more depth to ease interpretation of clinical data obtained from young puppies.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,002 | 0,000 |
| Bibliométrie | 0,003 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».