IRL-1620 Increases the Efficacy of Radiation Treatment in Mice Bearing Lymphoma Cell Induced Tumors.
Notice bibliographique
Résumé
Abstract PURPOSE. IRL-1620, a selective ETB receptor agonist, has been reported to selectively enhance tumor blood flow and potentiate the efficacy of chemotherapeutics in various tumor models. Improved tumor perfusion is associated with a net increase in tumor oxygenation, which may be exploited to increase the effectiveness of radiotherapy. Since tumor oxygenation increases the radiation-induced cellular damage, IRL-1620 may be helpful to increase radiation sensitivity of tumor. The present study was conducted to determine whether administration of IRL-1620 prior to radiation enhances the efficacy of radiotherapy. STUDY DESIGN. Male Swiss albino mice (6–8 weeks old; 25–30 g) were used for the study. Tumor was induced by the subcutaneous inoculation of Dalton’s Lymphoma cells (1 million) on the right hind limb. Tumor volume was measured using a digital caliper. Animals with a tumor volume of about 1cc were selected for the study and were divided into six groups (10 mice per group). Group I: No treatment; Group II: IRL-1620 (9 nmol/kg, 5 doses on alternate days); Group III: Radiation (5 × 4 Gy using Cobalt-60 Teletherapy unit (Theratron 780, Canada) on alternate days administered at 1 Gy/min); Group VI: IRL-1620 (1 nmol/kg) + radiation, 5 doses on alternate days; Group V: IRL-1620 (3 nmol/kg) + radiation, 5 doses on alternate days; Group VI: IRL-1620 (9 nmol/kg) + radiation, 5 doses on alternate days. Mice were shielded with lead except for a 3-cm-diameter circular field where the tumor was centered. IRL-1620 was administered via tail vein 15 minutes prior to radiation administration. Tumor diameter was measured twice a week for a total of 70 days. RESULTS. Tumor bearing mice without any treatment showed a progressive increase in tumor volume and all the animals died by 53 days after tumor induction. Radiation alone did not significantly reduce tumor volume when compared to controls (possible due to hypoxic condition). There was no significant increase in the survival. All the animals (10 out of 10) died by 56 days after tumor induction. Animals treated with radiation 15 min after administration of 9 nmol/kg IRL-1620 reduced the tumor volume significantly and there was significant increase in life span. It was found that only 4 out 10 animals died by 70 days after tumor induction. Animals treated with radiation 15 min after administration of 3 nmol/kg IRL-1620 delayed the development of tumors. It was found that 7 out 10 animals died by 70 days after tumor induction. Animals treated with radiation 15 min after administration of 1 nmol/kg IRL-1620 along with radiation delayed tumor development. It was found that 9 out 10 animals died by 70 days after tumor induction. CONCLUSION. It is concluded that IRL-1620 significantly enhanced the efficacy of radiation treatment in Dalton’s Lymphoma cells induced tumor model by reducing tumor volumes and increasing the survival.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».