PHYSICAL ACTIVITY ACROSS THE LIFE COURSE AND RISK OF PRE- AND POST-MENOPAUSAL BREAST CANCER
Notice bibliographique
Résumé
Background: Moderate-to-vigourous intensity physical activity (MVPA) is among the few modifiable factors known to reduce breast cancer risk.However, the independent effects of leisure-time, household, and occupational MPVA by age period across the life course remain poorly understood.Whether these effects differ by menopausal status and by tumour subtypes defined by the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) is unknown.An understanding of these issues will help advance policy and public health action targeting breast cancer prevention through physical activity.Methods: A case-control study of 1,011 incident breast cancer cases and 1,014 cancer-free controls aged 40-80 years was conducted from 2006-2010 in Vancouver, British Columbia (BC).Lifetime leisure-time, household, and occupational MVPA were assessed by questionnaire and mean MET-hrs/week of each were calculated for age periods 12-17, 18-34, 35-49, and 50 years and the total lifetime.Odds ratios for pre-and post-menopausal breast cancer risk associated with each activity domain across age periods were estimated using unconditional logistic regression, and odds ratios for risks of ER/PR-defined and ER/PR/HER2-defined breast tumours were estimated using unconditional polytomous logistic regression.Results: Among post-menopausal women, lifetime leisure-time and household MVPA reduced breast cancer risk by approximately 50% at volumes equal to 3 hours per week of running and 21 hours per week of active household work.MVPA reduced risk at all age periods across the life course, particularly during adulthood.Effects of leisure-time MVPA appeared restricted to HER2tumours.Household MVPA reduced risk for ER/PR+ tumours, regardless of HER2 status.MVPA iii was not associated with pre-menopausal breast cancer risk, except occupational MVPA performed during ages 18-34 was associated with a doubling in risk.Conclusions: MVPA is a lifestyle factor women may engage in to reduce post-menopausal breast cancer risk.Results suggest HER2 may be implicated in anti-breast carcinogenic effects of leisure-time MVPA.Increased risk associated with occupational MVPA may be due to occupational exposures related to job intensity.Further research on specific aspects of weekly MVPA energy expenditure dose required to reduce breast cancer risk will aid in refining physical activity recommendations for breast cancer prevention.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».