Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) Study of Respiratory Syncytial Virus-Associated Deaths in Pediatric Patients in Canada: A Retrospective Review From 2003 to 2013
Notice bibliographique
Résumé
Background. Respiratory syncytial virus (RSV) is a major cause of pneumonia and the major cause of bronchiolitis in infancy. Mortality rates in previously healthy infants with RSV pneumonia and bronchiolitis are less than 0.5%, but rates are higher in severely immunocompromised patients. Although mortality is rare, such cases do occur. To this end, data are lacking for the risk factors associated with mortality from RSV infection among children in Canada. The objective of this study was to determine the number of RSV-related deaths and the factors associated with these deaths among children hospitalized with RSV infection in Canadian pediatric centers. Methods. Retrospective review of all RSV-associated deaths at centers affiliated with the Pediatric Investigators Collaborative Network on Infections in Canada over the period 2003–2013, inclusive. Cases were identified using similar International Classification of Diseases codes to capture all deaths where a diagnosis of RSV infection was also present. Results. Overall, 8 centers reported 66 RSV-associated deaths. Respiratory syncytial virus was regarded as primarily responsible for deaths in 27 (41%) of cases. The median age of children who died was 11 months (range, <1 month to 16 years). Twenty-five patients (38%) were male. Thirteen deaths (20%) occurred among patients with no known risk factors for severe RSV. Thirty-eight deaths (58%) were among patients who had underlying chronic medical conditions without known immune deficiency, whereas 14 (21%) occurred among immunocompromised hosts. Community-acquired infections accounted for 43 deaths (65%). Fifty-five subjects (83%) were admitted to an intensive care unit and received mechanical ventilation. Palivizumab use was reported in 4 (6.1%) and 3 (4.6%) subjects for prophylaxis and treatment, respectively. Ribavirin use for treatment was reported in 8 (12%) subjects. Conclusion. Respiratory syncytial virus-associated deaths were predominantly associated with chronic medical conditions and immunocompromised states among infants. However, 1 of every 5 deaths occurred among infants with no known risk factors for severe RSV. Deaths associated with nosocomially acquired infections were observed. Further study of the factors (e.g. immunogenetic) associated with deaths is warranted. Disclosures. J. Papenburg, Becton, Dickenson and Co.: Investigator, Research grant. RPS Diagnostics: Board Member, Consulting fee AbbVie Inc: Board Member, Consulting fee; J. M. Langley, GSK: Investigator, Research support
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,002 | 0,002 |
| Bibliométrie | 0,006 | 0,016 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».