Invasive Pneumococcal Disease (IPD) in Children and Adults Following Introduction of Pneumococcal Conjugate Vaccines: Data From Population Based Surveillance 2001–2015
Notice bibliographique
Résumé
Background. In Ontario, PCV7 was publicly funded in Januar 2005 (3 + 1 schedule), PCV10 in October 2009 and PCV13 in November 2010 (2 + 1 schedule with catchup for up to 35 months old). TIBDN performs population-based surveillance for invasive pneumococcal disease (IPD) in Toronto/Peel to evaluate program impact. Methods. IPD cases are reported to a central office and 1 isolate/case is serotyped (ST). Demographic and clinical data are collected by chart review and patient/physician interview. Results. From 2001 to 2015, 6594 IPD cases were identified and ST was available for 6046 (92%). Sixteen percent of cases were aged <15 years). 28% required ICU admission. Presenting diagnosis were pneumonia (68%), bacteremia without focus (17%) and meningitis (7%). The IPD rate decreased from 8 to 7/100,000/year (2005/2010 versus 2013/2015) in adults and from 11 to 5/100,000/year in (2009 versus 2013/2015) in children. Since the introduction of PCVs, non-PCV ST IPD has increased from 2.6 to 4/100,000/year in adults and from 1.3 to 3.5/100,000/year in children (2001/4 versus 2013/5). IPD due to ST23A has increased in adults from 0.1 to 0.2 in 2001/2004 to 0.3 to 0.4/100,000/year in 2013/2015; and from no cases in children in 2001/2007 to 0.2–0.6/100,000/year in 2013/2015. In 2014/2015, STs were available for 88% of cases; STs 22F (12%), 19A (10%), 3 (9%), and 23A (7%) were the most common in adults. STs 19A (22%), 22F (10%), 3 (10%), 15B (8%), and 15C (8%) were the most common in children. Non-PCV STs represented 70% of cases in 2015. From 2013 to March 2016, 165 pediatric IPD cases were identified. ST was available for 143 (87%). Forty-five were due to PCV13/non7 STs. Seven were ineligible for PCV13 (aged >35 months when catch-up program was implemented or <2 months of age or immigrated to Ontario at age >35 months). Vaccine history was available for 34 PCV13 vaccine-eligible children with PCV13/non7 ST disease (10 in 2013, 14 in 2014, 7 in 2015, and 3 in January–March 2016). Six were unvaccinated (4 ST19A, 2 ST3), 11 missed ≥1 scheduled doses (8 ST19A, 2 ST3, 1 ST7F); 7 were eligible for a single dose only (2 ST19A, 5 ST3); 1 (ST3) was a child (11 months) who received doses at 2 and 4 mos; and 9 were vaccine failures (6 ST19A, 2 ST3, 1 ST5). Conclusion. Since PCV13-program implementation, the IPD rate due to PCV13/not7 STs has decreased in children and adults. NonPCV ST IPD has increased and in 2015 represented 70% of cases. Disclosures. A. McGeer, Pfizer Canada: Grant Investigator and Scientific Advisor, Research grant
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,002 | 0,004 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».