Mammographic density and familial breast cancer: Comparison of related and unrelated controls
Notice bibliographique
Résumé
B78 Background: Mammographic density (MD) is a strong and highly heritable risk factor for breast cancer with features of an intermediate phenotype for breast cancer. Some of the genes associated with MD may also be associated with risk of breast cancer, and MD may explain some of the effect of family history on risk. We would like to examine whether mammographic density is a risk modifier for women with a family history of breast cancer or who are carriers of BRCA1 or 2 mutations. However, family history and ethnicity are both very complex variables, and thereby more difficult to match. Sister controls may have an advantage, as you are able to match completely on the more difficult variables that have been shown to influence density. As density is largely genetically determined, this may result in overmatching on MD between the case and the related controls. This study seeks to examine the potential effects of using controls related to cases (e.g. sisters) or unrelated controls. >Methods: We formed triplets each consisting of a case diagnosed with invasive breast cancer, a full-blood unaffected sister, and an unrelated control. There were 236 triplets, for a total of 708 participants with mammograms. They were all matched within five years to age at mammogram. Randomly ordered images were measured “blindly” without any knowledge of the subjects. Total breast area and mammographic dense area were measured, and percent mammographic density, the outcome variable, calculated from these two measurements. >Results: We compared percent MD in cases and 2 groups of controls. One control group were unaffected sisters of the cases (n=236 case-control pairs), and other control group was comprised of 236 unrelated individuals. Statistically significant correlations in MD were seen between cases and their sister controls (r= 0.40 (95% CI: 0.28, 0.50; p Conclusions: The difference in mammographic density between cases and controls were similar for sister and for unrelated controls. The use of sisters as controls does not therefore introduce overmatching on MD, but does have the advantage of reducing the variance in the difference in MD between cases and controls.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».