P746 Clinical characteristic of Crohn's disease patients in Polish population
Notice bibliographique
Résumé
Background: There is a common impression that the incidence and prevalence of Crohn's disease (CD) in the Polish population have been rising in recent years. In 2005, a nationwide Crohn's disease registry in Poland was established to collect demographic and clinical data of patients diagnosed with Crohn's disease. The aim of presented study was to characterise demographic and clinical features of Polish population with CD, based on national registry data. Methods: In a collaborative, prospective registry of a consecutive CD patients conducted in 95 gastroenterology centers across the country 5942 adult patients have been enrolled. Patient's phenotype according to: Montreal classification, demographics, smoking, family history, comorbidity, extraintestinal manifestation, medical treatment and surgical interventions have been evaluated. Results: The age of diagnosis of CD in polish population was under 40 in more than 77% of patients [22.8% <16 (A1), 55.2% 17–40 (A2)] and only in 22% over 40 (A3). Although there was no gender difference in the overall population (males/females ratio 1.025), males predominated among young patients (759/565 in <16 group and 1723/1474 in 17–40 group, p<0.001). Males more often sustain penetrating disease and localization in ileum and upper gastrointestinal tract. On the other hand females more often suffer from extraintestinal manifestations. The location of the disease was as follows: ileal (L1): 13.4%, colonic (L2): 30.3%, ileocolonic (L3): 56%, upper gastrointestinal tract (L4): 9.9%. The disease behaviour presented: non stricturing, non penetrating (B1): 58.6%, stricturing (B2): 28%, penetrating (B3): 19.8%, perianal disease (p): 26.4%. The disease was more common in urban areas and in patients with higher education. Family history was positive in 4.4%. Rheumatoid arthritis among women (2.6%) and ankylosing spondylitis among men (1.1%) were the most prevalent coexisting diseases. There were more smokers among men than women (15.6% vs. 11.0% p<0.001). Smoking was associated with a higher risk of strictures (36.4% vs 28.5%, p<0.001), abscesses (19.3% vs 15.3%, p=0.013) and overall need for surgery (41.8% vs 30.5%). However smokers less likely suffer from extraintestinal manifestations and localization in upper gastrointestinal tract. 31.6% of the patients had at least one surgery. Conclusions: The prevalence of IBD in this cohort falls in the intermediate range of that reported for white populations in Europe and North America. Young age of diagnosis, smoking and male gender are the main risk factors for the complications, which will require surgery. Future studies are needed to examine more local risk factors and epidemiologic time trends.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».