P192 Heartburn in Crohn's disease is associated with increased disease activity, poor sleep quality and prior ileocecectomy
Notice bibliographique
Résumé
Background: Patients with Crohn's disease (CD) commonly report symptoms of heartburn, however the prevalence, predisposing factors, and relationship between heartburn and CD are not known. We assessed the prevalence of heartburn in patients with CD and investigated the association between gastro-oesophageal reflux disease (GORD) and CD manifestations, treatment, and sleep quality. Methods: We recruited patients (pts) with CD from an ambulatory clinic at a tertiary care inflammatory bowel disease center. Pts completed a survey that included the validated GORD Health Related Quality of Life (GORD-HRQL) instrument and Pittsburgh Sleep Quality Index (PSQI). We abstracted clinical data from medical records including medical history, CD classification, medications, and Harvey-Bradshaw Index (HBI). Simple statistical analysis was performed for univariate associations, followed by multivariate logistic regression analysis. Results: 111 pts with CD were included in the analysis. The mean age was 42 years, mean body mass index (BMI) was 26.31, and the population was 60.4% female. The most common Montreal classification was A2 (59.5%), L3 (55.0%, 9.9% L4), and B1 (50.5%). 63.9% of pts with CD reported heartburn. Pts with and without heartburn were of similar age, sex, smoking status, location of disease, and disease behavior. Pts with heartburn had a higher mean BMI and less frequent alcohol use (Table 1). Female sex (OR 3.06 (95% CI 1.18–7.90), p=0.02), BMI (OR 1.12 (1.03–1.22), p=0.01), alcohol use (OR 0.47 (0.24–0.90), p=0.02), current steroid use (OR 3.70 (1.17–11.67), p=0.03), and history of ileocecectomy (IC) (OR 4.27 (1.41–12.89), p=0.01) were associated with heartburn (Table 2). Pts with heartburn reported less satisfaction with their current condition (p=0.005), worse sleep (PSQI mean 7.35 v. 4.63, p<0.001), and higher mean HBI (2.54 v. 1.20, p=0.017). Pts within 5 years of IC had a similar rate of heartburn as those whose surgery was more than five years prior, but of less severity (GORD-HRQL 4.30 v. 12.05, p=0.02). Table 1. Characteristics of patients reporting heartburn symptoms compared to patients that do not report heartburn symptoms Table 2. Multivariate analysis of factors to predict the presence of heartburn symptoms in Crohn's disease determined by logistic regression OR = Odds Ratio; CI = Confidence Interval. Conclusions: Heartburn in CD is associated with poor sleep quality and increased disease activity. In addition, we newly identified prior IC as a risk factor for heartburn in CD, which may reflect motility alterations due to surgery or fibrosis in these pts. Further investigation into heartburn in CD pts and its management is warranted.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».