P734 The sex ratio of inflammatory bowel disease varies according to age at onset: results from a worldwide survey
Notice bibliographique
Résumé
Background: Among patients with inflammatory bowel disease (IBD), age is a strong and well-known determinant of disease risk. Although peak incidence rates according to age have been widely reported, little is known about how these estimates vary according to sex. We aimed to explore the incidence of Crohn's disease (CD) and ulcerative colitis (UC) according to age and sex in population-based studies across the world. Methods: A comprehensive literature search was conducted to identify representative population-based cohorts with IBD incidence data available for the full age spectrum starting from birth divided into 5-year or less intervals. Authors and guarantors of these cohorts were invited to share their data as collaborators. Background population data were also obtained. Incidence rates for CD and UC were calculated according to age and sex. We pooled incidence rate ratios (pIRR) for males:females (M:F) by random-effects meta-analysis according to the method of Desimonian and Laird. Results: Data from 22 population-based or nationwide cohorts from 1988–2013 were included in the analysis. Among 269,136,094 males and 277,683,752 females, there were 69,689 total cases of CD (32,300 M/37,389 F) and 80,739 total cases of UC (41,807 M/38,932F). In CD, males younger than age 15 had a significantly higher incidence, peaking between age 10–14, compared to females (pIRR age 10–14 M:F 1.53, 95% CI: 1.39–1.68, p<0.001). There was an inversion of sex ratio after age 15, with females having increasingly higher incidence of CD, reaching statistical significance after age 40–44 (pIRR age 40–44 M:F 0.83, 95% CI: 0.74–0.94) [Figure 1]. Age of onset for UC in males and females was similar until age 40–44 (pIRR age 40–44 M:F 1.17, 95% CI: 1.0–1.36), after which males had a significantly higher incidence rate compared to females until age 75 (pIRR age 75–89 M:F 1.39, 95% CI: 1.03–1.87) [Figure 2]. Figure 1. Crohn's disease age of onset according to sex worldwide. Figure 2. Ulcerative colitis age of onset according to sex worldwide. Conclusions: Worldwide, there is significant variability in the sex ratio of IBD according to age at onset with males having higher incidence of CD before the age of 15, after which there is a female predominance, with an opposite trend in age at onset for UC where there is a striking male predominance after age 40. Variations in incidence rates according to sex across the globe may help identify unique, previously unrecognized genetic and environmental risk factors.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,011 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,003 |
| Bibliométrie | 0,002 | 0,007 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».