Determinants of breast tissue composition in young women
Notice bibliographique
Résumé
B153 Background . Variations in breast tissue composition in middle life, as shown by the extent of radiologically dense (fibroglandular) breast tissue, are strongly associated with differences in risk of breast cancer. Although dense breast tissue is most common at early ages, and decreases in frequency with increasing age, little is known about the factors that influence breast density at early ages. > Methods. Recruitment of healthy young women (aged 15-30 years) and their mothers took place at local schools and mammography clinics. We used magnetic resonance (MR) imaging to generate quantitative estimates of the fat and water content of breast tissue in young women. We examined factors likely to be associated with variation in these measurements, in particular the relationship with lifestyle factors and hormones and growth factors that influence the growth and development of breast tissue. All MR studies were carried out during the follicular phase of the menstrual cycle, and blood was taken for hormone assays on the day of the study. Mammograms from the mothers of the young women examined were obtained and measured for density, and a subset of mothers also had MR studies. > Results. To date 254 young women have been examined. The water content of the breast on MR is shown to be highly variable and correlated with blood levels of growth hormone and sex hormone binding globulin. No correlation is seen for total estradiol, testosterone, progesterone, prolactin or insulin-like growth factor-I. The water content of the breast in young women is also correlated with the measured dense tissue in the mammograms of their mothers. Among mothers, mammographic density and water content by MR are also strongly correlated. Further, environmental factors, including current use of oral contraceptives and use of soy-based infant formula are associated with variations in breast water content. > Conclusion. The tissue composition of the breast in young women is highly variable and associated with variations in circulating levels of growth hormone, a breast mitogen. The mother-daughter correlation is consistent with a genetic influence. The environmental findings suggest potential mechanisms for effects of these environmental factors on breast cancer risk.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».