P703 Risk of disease progression in patients with Crohn's disease after 7 years of follow-up in a Danish population-based inception cohort
Notice bibliographique
Résumé
Background: Crohn's disease (CD) is a progressive disease that over time can lead to the development of complications such as strictures or internal penetrating disease that will ultimately lead to surgery. Only few population-based studies have investigated the risk factors for disease progression in CD including the effect of smoking. We therefore sought to identify the risk factors associated with complicated CD in a Danish population-based inception cohort from the biological era. Methods: All incident patients diagnosed with CD or UC in a well-defined Copenhagen area 1.1.2003–31.12.2004 were registered and followed prospectively until 31.12.2011. Clinical data including medical and surgical treatment and disease phenotype according to the Montreal classification were registered. Disease progression in CD was defined as the first occurrence of a bowel stricture (B2) or internal penetrating disease (B3), defined by endoscopy, cross-sectional imaging or surgery, or the need for non-perianal surgery. Possible associations between disease progression and multiple covariates (age, gender, disease location, type of medical treatment, diagnostic delay and smoking status) were analysed by Cox regression analyses using the proportional hazard assumption. Results: The cohort consisted of 213 incident CD patients that were followed prospectively. Of those, a total of 165 (77%) patients had non-penetrating, non-stricturing disease behaviour (B1) at diagnosis and were included in the analysis. Of those with B1, 44 (27%) patients experienced progression of disease during the seven year follow-up: 21 (48%) B2, 5 (11%) B3, and 18 (41%) had surgery. Patients with ileal disease location (L1 or L3) had increased risk of disease progression (HR =2.1 CI95%: 1.1–4.0) as was also seen in patients who did not receive medical treatment during follow-up compared to those who did (HR =9.0 CI95%: 3.3–25.0). Other covariates including active smoking at the time of diagnosis were not associated with the risk for a disease progression. Conclusions: In this population-based inception cohort of unselected CD patients one out of four patients with B1 behaviour at diagnosis experienced disease progression during follow-up. Clinical variables associated with the risk of progression were ileal disease location and not receiving medical treatment for CD. Smoking was not associated with the risk of disease progression in CD.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».