P505 Efficacy of MMX-mesalamine monotherapy for maintenance of remission in ulcerative colitis patients after mucosal healing
Notice bibliographique
Résumé
Background: Mucosal healing has become a common endpoint in most ulcerative colitis (UC) clinical trials as well as an important objective in clinical practice. Mucosal healing in UC patients is associated with high rates of clinical remission and a favorable prognosis. MMX-mesalamine is a drug that due to its pharmacokinetics characteristics reaches more distal segments of the colon. Thus, it could be used in patients with intolerance to topical therapy. The aim of this study was to evaluate the efficacy of MMX-mesalamine for maintenance of remission in UC patients after mucosal healing. Methods: A prospective, observational cohort study was designed. Consecutive UC patients with demonstrated mucosal healing at colonoscopy, and who were under monotherapy with MMX-mesalamine were included. Patients receiving additional topical therapy were excluded. Extension of the disease was classified according to the Montreal Classification. Mucosal healing was defined as endoscopic Mayo sub-score of 0 or 1. In order to avoid interpretation bias, all colonoscopies were performed and scored by the same endoscopist, who is an expert in IBD. Clinical relapse was defined as the need for remission induction treatment, any treatment escalation, hospitalization or colectomy. In order to assess the clinical course of UC, patients were followed-up and clinical relapses were evaluated at months 6 and 12 from initial colonoscopy. The influence of demographic and clinical variables (smoking, extension of disease and Mayo sub-score) in the clinical course of UC was also evaluated. Results are shown as percentages and analyzed by the chi-squared test and logistic regression. Results: 57 UC patients fulfilled the inclusion criteria and were finally included. Mean age was 48 years (range 33–58), 58% women; 44% had never smoked, 19% were active smokers and 37% former smokers. 51% were E1, 26% were E2 and 23% were E3. Sixty-five percent had Mayo 1 and 35% had Mayo 0. During the first six months of follow-up 79.1% of patients remained in remission and 20.9% relapsed (mean time to relapse 14 weeks). Over the second semester, an additional 7% of patients relapsed. 10 out of the 12 patients who relapsed had a Mayo 1 sub-score. Frequency of relapses was not different in the different Montreal groups (p=0.78). 83% of former smokers patients presented a relapse compared to 17% of non-smokers (p=0.06). Conclusions: MMX-mesalamine appears to be effective to maintain endoscopic remission in UC patients. Neither the extension of the disease nor the Mayo sub-score seem to influence the efficacy of the therapy in this study. Further studies including larger numbers of patients are required to confirm these data.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».