P658 The Inflammatory Bowel Disease Disability Index (IBD-DI) in ulcerative colitis is related to disease activity, need of immunosuppressive therapy and quality of life
Notice bibliographique
Résumé
Background: IBDs are disabling conditions that negatively affect physical, psychological, familial and social dimensions of life. Thus, specific tools have been used to assess the impact of disease and its treatment options on relevant end-points such as health-related quality of life (HRQL), measured by the IBD-Questionnaire (IBD-Q). Recently, the IBD-Disability Index (IBD-DI) has been developed to evaluate the entire spectrum of limitations in functioning in patients (pt) with IBD. This index is inspired to the ICF. The aim of the present study was to assess the relationship between the IBD-DI, clinical characteristics and HRQoL in a cohort of Sicilian pt with ulcerative colitis (UC). Methods: IBD-Q and IBD-DI questionnaires were administered to consecutive UC adults outpatients from July to November 2016. The IBD-DI consists of 28 items that evaluate the 4 domains of body functions, activity and participation, body structures and environmental factors. A higher score indicating a greater level of disability. IBD-Q consists of 32 questions grouped into 4 dimensions: bowel, systemic, social, emotional. Scores range from 1 to 7 with higher scores indicating better QoL. Disease activity was assessed by partial Mayo score. The mean differences of DI score in relation to dichotomic clinical variables were performed by Student's t test. By linear regression analysis we assessed also the relationship between DI and IBD-Q. Differences were reported as statistically significant if the pvalue was<0.05. Results: 49 UC patients (69% males, median age 47 years) were enrolled; 24% were smokers. 75% had inactive or mild disease, 12 (25%) moderate disease. None of the recruited pt had severe disease. Concomitant medications at the time of the interview were conventional therapy in 32 pt (65%) or immunosuppressants in 12 pt (24%). 4 pt took no medications and 1 patients was on topical therapy. The mean IBD-DI score was 25.49±19.83; 59% of patients had low DI≤25 while 14% had high DI (>50. No correlations were found between IBD-DI and gender, disease duration, disease extension (Montreal Classification) and extraintestinal manifestations. IBD-DI was related to clinical disease activity (p=0.006) and immunosuppressive therapy (p=0.060). By linear regression analysis, IBD-DI was significantly associated with IBD-Q (R2 0.693; p<0.001.Interestingly, 8% (n=4) of patients with inactive or mild disease had severe disability (>50) and 6% (n=3) with active disease had low disability (<25). Figure 1 Conclusions: Our preliminary results show that the IBD-DI is a reliable tool to measure functional status and disability in UC; it correlates with disease activity, need of immunosuppressive therapy and HR-QoL. This novel index should be adopted as a primary endpoint in disease modification trials.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,006 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».