MP47-16 CURRENT DELAYS FROM BIOPSY TO RADICAL PROSTATECTOMY DO NOT APPEAR TO AFFECT PATHOLOGIC OUTCOMES IN LOW, INTERMEDIATE, OR HIGH-RISK DISEASE
Notice bibliographique
Résumé
You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy IV1 Apr 2017MP47-16 CURRENT DELAYS FROM BIOPSY TO RADICAL PROSTATECTOMY DO NOT APPEAR TO AFFECT PATHOLOGIC OUTCOMES IN LOW, INTERMEDIATE, OR HIGH-RISK DISEASE PREMAL PATEL, Leanne Ross, Kiril Trpkov, and Geoffrey Gotto PREMAL PATELPREMAL PATEL More articles by this author , Leanne RossLeanne Ross More articles by this author , Kiril TrpkovKiril Trpkov More articles by this author , and Geoffrey GottoGeoffrey Gotto More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.1476AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There is a small volume of varied literature reporting on the impact of time between prostate cancer diagnosis on biopsy and definitive intervention with radical prostatectomy with regards to adverse pathological outcomes. There are considerable, and in some cases increasing, delays in treatment for patients with prostate cancer in Canada's publicly funded healthcare system. We sought to evaluate our institutional outcomes using a large multi-surgeon database. METHODS We retrospectively reviewed 2,728 patients who underwent radical prostatectomy between 2005 and 2014. Patients were stratified according to biopsy Grade Groups and pre-operative PSA levels. Pathologic outcomes were evaluated for patients with <2 months between biopsy and surgery and then at monthly intervals of up to 6 months. Adverse pathological outcomes were defined as Gleason upgrading from biopsy, the presence of extracapsular extension (pT3a) or seminal vesicle invasion (pT3b), positive surgical margins and positive lymph node involvement. The x2 test was used for statistical analysis. RESULTS In total 2310 patients met our inclusion criteria. Median time from biopsy to surgery was 83 days (range: 61-109). Grade groups 1, 2, 3, 4, 5 comprised of 906 (39.2%), 1,048 (45.4%), 231 (10%), 69 (3%) and 56 (2.4%), respectively. In total 31.8% of patients were upgraded by Grade Group on final surgical pathology. The overall positive surgical margin rates were 25% for organ confined (pT2) disease and 49.8% patients with pT3 disease. Lymph node involvement was identified in 1.5% of patients. There was no observed difference in adverse pathologic outcomes for patients in any risk category with delays of up to 6 months between biopsy and radical prostatectomy. CONCLUSIONS Surgical delays of up to 6 months following prostate biopsy were not associated with an increased risk of Gleason score upgrading, extracapsular extension, seminal vesicle invasion, positive surgical margins, or lymph node involvement. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e634-e635 Advertisement Copyright & Permissions© 2017MetricsAuthor Information PREMAL PATEL More articles by this author Leanne Ross More articles by this author Kiril Trpkov More articles by this author Geoffrey Gotto More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,015 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,007 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».