WOMAC Pain Scores at the Time of ACL Injury are Associated with Concentrations of Serum and Urine Biomarkers of Type 2 Collagen Degradation at the Time of ACL Reconstruction
Notice bibliographique
Résumé
Objectives: Individuals sustaining anterior cruciate ligament (ACL) injuries are at increased risk for post-traumatic osteoarthritis (PTOA). Methods to discern early physiologic changes associated with PTOA are lacking. Surrogate measures of OA that may include soluble biomarkers of cartilage metabolism and pain measures have been correlated with early OA development as well. It was the objective of this study to determine whether serum biomarkers related to Type II collagen metabolism are associated with pain measures at an early time point after ACL injury. Methods: Cadets at a U.S. Service Academy who sustained primary ACL injuries were enrolled in a prospective cohort study to evaluate the relationship of WOMAC Pain Scores with serum and urine levels of C2C. C2C is an epitope of Type II collagen produced by the breakdown of the Type II collagen fibrils in articular cartilage. Questionnaires assessing the WOMAC score were completed at the time of injury with serum and urine samples obtained at the time of ACL reconstruction. Commercially available C2C ELISA tests (Ibex Pharmaceuticals, Quebec, CA) were performed on the samples from subjects obtained at the time of surgery using kits from the same production batch and reported as ng/ml±SD. Pearson correlations were calculated with significance set at p≤0.05. Results: A total of 12 subjects met the inclusion criteria and had a questionnaire completed at time of injury and fluid samples obtained at the time of ACL reconstruction surgery. The average time from injury to the time of surgery was 30.7±15.5 days. The mean serum C2C concentration at the time of surgery was 1.12 ±0.20 ng/ml and the mean urine C2C concentration was 2.12±0.51 ng/ml. The mean WOMAC Pain score was 72±21 points. The WOMAC Pain scores at the time of initial injury were inversely correlated (r=-0.609 , p=0.036) with serum C2C concentrations at the time of surgery approximately 4 weeks later. WOMAC Pain scores at the time of ACL injury accounted for 37% of the variability in serum C2C concentrations at the time of ACL reconstruction (Figure 1A). Similar results were observed for the correlation between WOMAC Pain scores at the time of injury and urine C2C concentrations at the time of surgery. The WOMAC Pain scores at the time of initial injury were also inversely correlated (r=-0.759, p=0.004) with urine C2C concentrations at the time of surgery. WOMAC Pain scores at the time of ACL injury accounted for 58% of the variability in urine C2C concentrations at the time of surgery. Conclusion: We observed a strong inverse correlation between WOMAC Pain scores at the time of ACL injury and serum and urine C2C concentrations measured at the time of ACL reconstruction approximately 4 weeks later. These preliminary findings suggest that subjects who initially report greater deficits on the WOMAC Pain scale following ACL injury also appear to have greater concentrations of Type II collagen degradation markers in both serum and urine at the time of ACL reconstruction. These findings may have implications for subsequent OA risk following acute traumatic knee joint injury.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».