Uterine resectoscopic myomectomy with and without microrelin pretreatment: a single-blinded randomized clinical trial
Notice bibliographique
Résumé
Study objective: To assess the outcomes of surgery in the group of patients who were submitted to preoperative GnRH agonists in comparison with those who received no medication. The levels of gonadotropin hormones (LH and FSH) and estradiol, which were measured 2 and 12 weeks after treatment, were also compared between two groups. Design: Single-blinded randomized clinical trial. Design classification: Canadian Task Force Classification I. Setting: University hospital. Patients: A total of 60 patients participated in this clinical trial. Inclusion criteria were: age between 18-50 y (premenopausal women). Interventions: Sixty patients were assigned randomly to intervention and control group. Intervention group received three doses of monthly intramuscular injections of Microrelin 3.75 mg (a sustained release formulation of triptorelin) before hysteroscopic myomectomy and control group received no medications. Uterine resectoscopic myomectomy was performed in both groups. Measurements and main results: Operation characteristics including operation time and amount of absorbed fluid were measured. Level of difficulty and satisfaction from surgeon’s view were assessed based on Visual Analog Scale (VAS). Serum levels of LH, FSH and estradiol were measured at the baseline and after 2 and 12 weeks in both groups. A total of 60 patients participated in this clinical trial. The sizes of myomas were significantly reduced in microrelin group in comparison with control group (33% reduction, p<0.0001). The administration of Microrelin led to significant reduction of estradiol, LH and FSH levels after 12 weeks. However a transient flare-up in the level of estradiol was detected after 2 weeks. The satisfaction level from operation from surgeon’s view was significantly higher (p=0.01) and the level of difficulty was lower in Microrelin group (p=0.049). No significant difference in haemoglobin drop after operation was detected between two groups. Conclusion: Our study showed that pretreatment with Microrelin before uterine resectoscopic myomectomy could lead to less surgical difficulties and subsequently lower operation time. The amount of haemoglobin (as an indicator of blood loss) was not affected with this intervention. Our study supports the beneficiary influence of GnRH agonists in outcomes of myomectomy.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,005 | 0,007 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,002 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,004 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».