Correlations Amongst Mental Health, Cognitive Flexibility, and Zinc Status
Notice bibliographique
Résumé
Background: Cognitive flexibility impairment has been seen in both anorexia nervosa (AN) and commonly comorbid disorders, as have symptoms overlapping with those of zinc depletion. Zinc depletion and AN risk groups also have distinct overlap, and zinc has been found to play a role in neuroplasticity, which affects cognitive flexibility. Zinc supplementation has shown benefit in AN treatment, however the mechanisms for this benefit are unclear and have not been explored in detail. Research Question and Aims: The primary aim was to investigate correlations amongst mental health status, cognitive flexibility, and zinc status in order to better understand whether zinc supplementation benefits in anorexia nervosa (AN) are due to metabolic alterations or to mental health changes which in turn impact behaviour. The secondary aim was to better characterize the Bryce-Smith zinc taste test (ZTT) in order to understand its potential as a clinical measurement method for zinc status. Hypotheses: In regards to the primary aim, it was hypothesized that lower zinc status (as measured by the ZTT and reported symptoms of zinc depletion) would be associated with decreased cognitive flexibility measures and increased depressive, anxiety, obsessive compulsive, and eating disorder symptoms. In regards to the secondary aim, it was hypothesized that ZTT results would positively correlate with reported seasoning usage and reported zinc depletion symptoms. Methods: Participants were recruited via the University of Calgary’s Department of Psychology Research Participation System. The Perceived Stress Scale, Mental Health Inventory-38 anxiety subscale, Inventory of Depressive Symptoms-SR30, Compulsiveness Inventory, Obsessive Compulsive Inventory-R, and Eating Attitudes Test-26 were administered to all participants to quantify mental health status, while Trail Making Tests A/B, Berg’s Card Sorting Test, and the Haptic Illusion test were used to measure cognitive flexibility. The Bryce-Smith ZTT, and a zinc-related factors questionnaire were also administered. Results: 12 females aged 18-50 were tested and results analyzed using Spearman’s and Mann-Whitney U tests. No significant correlations were found between ZTT scores and measures used; however trends in directions that would support the hypothesis were observed. Conclusions: Due to small sample size and observed trends, it is suggested that the study be extended to expand the number and diversity of participants in order to better determine potential correlations and significance. It is also proposed that a rough estimate of intake of high-zinc foods (or another measure of zinc status) be used for better comparison.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».