57 Response to Iron Supplementation in Children with Autism Spectrum Disorder
Notice bibliographique
Résumé
Our main objective was to determine the change in serum ferritin level in response to iron supplementation in children with Autism Spectrum Disorder (ASD) seen at a tertiary level center. Our secondary objective was to document the relationship between low ferritin and low dietary iron. An open-label treatment trial was conducted with children who had previously demonstrated low serum ferritin measured during clinical diagnostic evaluations for ASD between 1998 and 2003. Diagnostic measures included the Autism Diagnostic Interview-Revised (ADI-R), Autism Diagnostic Observation Schedule (ADOS), and clinical evaluation. All children were prescribed 8 weeks of oral iron suspension or sprinkles. Dietary intake, compliance and side effects were tracked using a 3-day Food Record Form and a Nutritional Supplement Log. Serum ferritin and blood indices, including mean corpuscular volume (MCV) and hemoglobin (Hb) were measured at baseline and after 8 weeks of treatment. Thirty-three children completed the study (mean age 6 years 3 months, 35 males, 8 females); 85% had ferritin <22 μg/L and 30% had ferritin <12 μg/L. There were significantly more preschoolers with ferritin <12 μg/L (Chi2=6.9, p=.018), but there were no gender differences. Fifty-two percent of the sample had insufficient dietary iron intake; over half of these were preschoolers. Dietary sufficiency was not correlated with serum ferritin levels. Mean ferritin level increased significantly from 16 μg/L to 29 μg/L with a mean of 7 weeks of treatment (T=–5.02, p<.000). Ferritin level in 6 out of 8 preschoolers remained <12 μg/L despite treatment. At baseline, MCV was low in 42%, and Hb was below expected range for age in 9%. Mean MCV levels improved significantly with the treatment (T=–3.38, p=.002). No association was found between low ferritin and autistic symptomatology based on ADI-R or ADOS scores. Low serum ferritin is common in children with ASD. Signs of iron-deficient erythropoeisis were common, representing a more advanced stage of iron deficiency. Although mean ferritin levels increased overall with iron supplementation, the iron stores of a minority of children (all preschoolers) remained depleted following treatment. MCV improvement suggests some benefit from the treatment; this subset may require prolonged treatment to replete iron stores. These findings emphasize the importance of recognizing and treating iron deficiency in children with ASD.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».