Association analysis identifies 65 new breast cancer risk loci
Pourquoi ce travail est-il dans la base ?
Une base qui oublie comment elle a trouvé un travail ne peut pas être vérifiée. Voici les voies qui ont admis celui-ci.
Scores machine (provisoires)
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
- Écart entre enseignants
- 0,284 · la distance entre les deux têtes enseignantes sur ce seul travail
- Statut de validation
score_only:v0-immature-baseline· tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle
Résumé
Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours. Genome-wide association studies for breast cancer have identified common genetic variation that influences susceptibility to this disease, but much of the genetic risk remains unexplained. Doug Easton and colleagues report a genome-wide association study for breast cancer in more than 122,000 cases and 105,000 controls. The authors genotyped a subset of these cases using OncoArray, a new, custom genome-wide single-nucleotide polymorphism (SNP) array for cancer genomics. Overall, they identify 65 loci newly associated with breast cancer susceptibility, and estimate that, together with 107 previously identified breast cancer susceptibility loci, these explain about 18 per cent of the familial relative risk of breast cancer. Polygenic risk scores may be used in risk prediction models and may improve early detection and targeted prevention of the disease. Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry1. We identified 65 new loci that are associated with overall breast cancer risk at P < 5 × 10−8. The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. These results provide further insight into genetic susceptibility to breast cancer and will improve the use of genetic risk scores for individualized screening and prevention.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
La notice
- Revue
- Nature
- Thématique
- Genetic Associations and Epidemiology
- Domaine
- Biochemistry, Genetics and Molecular Biology
- Établissements canadiens
- University of British ColumbiaUniversity Health NetworkPublic Health OntarioSimon Fraser UniversityMcGill UniversityLunenfeld-Tanenbaum Research InstituteMount Sinai HospitalQueen's UniversityCentre Hospitalier de l’Université de MontréalUniversité LavalBC Cancer AgencyRoyal Victoria HospitalCentre hospitalier universitaire de QuébecMcGill University and Génome Québec Innovation CentreUniversity of Toronto
- Organismes subventionnaires
- National Cancer InstituteNational Human Genome Research InstituteFogarty International CenterNational Institute of Mental HealthCanadian Institutes of Health ResearchMedical Research CouncilMinistero dello Sviluppo EconomicoWorld Health OrganizationEuropean CommissionNational Institutes of HealthCancer Research UKGovernment of CanadaFondation du cancer du sein du QuébecGenome CanadaFrancis Crick InstituteNational Institute of General Medical SciencesMinistère du Développement Économique, de l’Innovation et de l’ExportationNational Institute for Health and Care Research
- Mots-clés
- Breast cancerOncologyAssociation (psychology)MedicineGeneticsBiologyComputational biologyCancerPsychology
- Résumé présent dans OpenAlex
- oui