Notice bibliographique
Résumé
Breast cancer has affected many women around the world throughout history. In order to recognize and treat the early signs of breast cancer, obtaining high quality images is crucial. A variety of imaging modalities are available for use in breast imaging, including conventional mammography and newer optical imaging techniques. One such optical imaging system is the ComfortScan™, which uses red light to image the breast and was the focus of this study. The objectives include investigating whether performing a large scale clinical trial with the ComfortScan TM would be warranted to further patient care and diagnostics for breast imaging, and determining whether the ComfortScan ™ would achieve better correlation to biopsy than mammography alone. An additional goal was to investigate whether the ComfortScan TM system would be beneficial as a mainstream method for a radiologist to diagnose breast cancer risk. The preliminary study with 19 patients demonstrated that there was no difference in diagnostic information between the near-infrared (NIR) image and mammography (p>O.OS). Anecdotal evidence suggests cases where mammography disagreed with biopsy, whereas ComfortScan TM agreed, though these were not statistically significant. Based on these encouraging results, a large scale clinical trial was launched to investigate the potential of widespread use of the ComfortScan ™. The large scale trial included 126 NIR images and found difference in diagnostic information between NIR and mammography (p The potential of using polyvinyl alcohol cryogel (PVA-C) as a breast tissue mimic was investigated and PV A -C was then used to validate the mode of action of the ComfortScan TM system. Two experimental methods reported the absorption coefficients and reduced scattering coefficients of PV A-C. Using a double integrating sphere, the values were J.la = 0.012 ± 0.002 mm-1 and J.ls' = 1.5 ± 0.2 mm-1 and using steady-state spatially resolved diffuse reflectance, the values were J.la = 0.017 ± 0.005 mm-1 and J.ls' = 1.3 ± 0.2 mm-1 at 640 nm. These values are comparable to typical absorption coefficients for tissue reported by others. The mode of action suggested by DOBI (Dynamic Optical Breast Imaging) Medical for the ComfortScan ™ system is that under compression a malignant tumour will highly attenuate light, due to a partial collapse in the tumourous vasculature, resulting in an increased deoxygenation of blood over time. Using a PV A-C breast mimicking phantom, it was shown that by deoxygenating horse blood in a cavity, there was an increase in the attenuation of 640 nm light as compared with the surrounding phantom material; which suggests that the colour representative of malignancies on the ComfortScan ™ is caused by deoxygenating blood. Further evidence suggests that the ComfortS can TM system is not recognizing a total collapse of the vasculature and subsequent void of blood from the tumour as the trigger for malignant detection. The mode of action suggested by DOBI Medical is supported by our findings.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,008 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,002 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».