Determination of Mercury in Aerosol by Inductively Coupled Plasma Mass Spectrometry
Notice bibliographique
Résumé
Summary Based on the knowledge gained from published studies, a new analytical method has been developed for the quantification of mercury (Hg) in the gas-vapor phase of mainstream cigarette smoke and in heated tobacco aerosol generated by a tobacco heating system (THS) using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). From a preliminary test, the mercury concentration in the particulate matter of mainstream smoke from Kentucky reference cigarettes 3R4F generated under the International Organization for Standardization (ISO) smoking regimen was compared with the mercury concentration in the gasvapor phase to assure that mercury is only measurable in the gas-vapor phase, as reported in an earlier published study. The particulate matter was collected using an electrostatic precipitation trap and was analyzed by ICP-MS after a mineralization step. The gas-vapor phase was trapped in the same smoking run as for the particulate matter using two impingers containing a nitric acid-hydrochloric acid-gold solution. The impingers were connected in series behind the electrostatic precipitation trap and the combined impinger solution was analyzed by ICP-MS after sample dilution without further sample treatment. The addition of gold has shown to be efficient for maintaining mercury in an ionized form in the impinger solution and to minimize the mercury memory effect in the sample introduction system of the ICP-MS. Only mercury in the gas-vapor phase could be quantified whereas the signal for mercury in the particulate matter was found close to those of blank solutions and was not measurable, as already mentioned in an earlier study. Following this preliminary test, the electrostatic precipitation trap was replaced by a Cambridge filter pad for the separation of the gas-vapor phase from the particulate matter where only mercury in the gas-vapor phase was quantified. The method for the quantification of mercury in the gas-vapor phase of aerosols obtained under Health Canada (HC) and ISO smoking regimens was validated according to International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) and Association of Official Analytical Chemists (AOAC) guidelines. Accuracy profiles were evaluated as described in Association Française de Normalisation (AFNOR). The regression curve was shown to be linear within the evaluated concentration range from 25 pg/mL to 1000 pg/mL with a weighting factor 1/x. The coefficients of variation for repeatability (r) were 3.6% for 3R4F and 4.8% for THS under HC smoking regimen and 3.6% for 3R4F and 4.6% for THS under ISO smoking regimen. The coefficients of variation for intermediate precision (IP) were 7.7% for 3R4F and 7.7% for THS under HC smoking regimen and 4.7% for 3R4F and 4.6% for THS under ISO smoking regimen. The nominal mercury concentrations for 3R4F obtained during the validation under both HC and ISO smoking regimens were found to be in line with results reported in a previously published CORESTA study.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».