A262 COLONIC MUCOSA-ASSOCIATED LYMPHOID TISSUE (MALT) LYMPHOMA, A RARE OCCURENCE: A LITERATURE REVIEW AND CASE SERIES
Notice bibliographique
Résumé
Extranodal mucosa-associated lymphoid tissue (MALT) lymphoma is a clonal B-cell neoplasm that develops in the marginal zone of lymphoid follicles. They make up about 5% of all non-Hodgkin’s lymphomas. The most common extranodal site for MALT lymphomas is the stomach, followed by the small bowel. Colonic MALT lymphomas are rare and, as a result, there are no guidelines for the workup and management of these lymphomas. This case series aims to review the literature of existing cases of colonic MALT lymphoma and to share our experience with diagnosis, workup and management of colonic MALT lymphoma. A literature search was conducted using an advanced PUBMED search. Charts of 4 identified cases diagnosed in 2016 - 2017 were reviewed. A literature review of colonic MALT lymphomas revealed a few dozen cases, either isolated or in conjunction with MALT in the upper GI tract. Presenting symptoms included abdominal pain, gastrointestinal bleeding, positive fecal occult blood test and weight loss. Workup included colonoscopy and biopsy, endoscopic assessment of the upper GI tract to assess for other foci of MALT lymphoma as well as testing for Helicobacter pylori and celiac testing, which have both been associated with gastric MALT lymphomas. Endoscopically they can appear as a polyp or mass with a smooth surface with changes in vascular pattern, but can be ulcerated if more advanced. The management of colonic MALT lymphoma varies. Patients with limited disease were often treated with radiotherapy, surgical resection or endoscopic resection via endoscopic mucosal resection or endoscopic submucosal dissection. Patients with multiple foci of disease or lymph node involvement were usually treated with chemotherapy and/or rituximab. There have been reports of resolution of the colonic MALT lymphoma after H. pylori treatment, even in patients who were H. pylori negative. We present our experience with the diagnosis and management of 4 cases of colonic MALT lymphoma. This includes cases of asymptomatic colonic MALT lymphoma diagnosed on routine colonoscopy which were treated conservatively with close monitoring, and a case with a concurrent gastrointestinal stromal tumor (GIST) in the stomach. In the latter case, the MALT lymphoma was treated with chemotherapy and rituximab with good response, and the GIST was surgically resected. Colonic MALT lymphomas are considered to be rare; however, the diagnosis of 4 cases at our institution in the last 2 years would suggest otherwise. Therefore, endoscopists should be familiar with this condition and its endoscopic features. Patients with asymptomatic, limited stage colonic MALT lymphoma can be managed conservatively. Although we report one case of colonic MALT lymphoma occurring concurrently with a gastric GIST, there is no clear association between the two conditions. None
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,003 | 0,001 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».