P274 Factors driving treatment escalation in Crohn’s disease in the CALM trial

Patients with Crohn’s disease (CD) from the tight control (TC) management group of CALM, whose treatment was escalated based on clinical symptoms and biomarkers (CD Activity Index [CDAI], C-reactive protein [CRP], faecal calprotectin [FC] and/or prednisone use), achieved better endoscopic outcomes than patients whose treatment was escalated based on CDAI and prednisone use only.1 The majority of decisions to escalate in the TC group included FC followed by CRP, CDAI, and prednisone use, however, a detailed algorithm of treatment decisions based on the four criteria has not been described. This analysis reports treatment escalation decisions in the TC group in more detail. A total of 122 patients naïve to biologics and immunosuppressants with or without prior prednisone use were randomised to the TC group. At randomisation, patients received treatment with adalimumab (ADA) induction 160/80 mg and then 40 mg every other week (EOW) if they met at least one criterion, i.e., CDAI ≥150, CRP ≥5 mg/l, FC ≥250 μg/g, and prednisone use. At 12, 24, and 36 weeks after randomisation, patients, who met at least one of the CDAI, CRP, FC, or prednisone criteria were escalated consecutively to the next treatment option (ADA 40 mg every week [EW], followed by ADA 40 mg EW+2.5 mg/kg azathioprine). Patients who did not meet a treatment escalation criterion were to stay at the same treatment. CDAI, FC, CRP and prednisone use were assessed one week before randomisation and treatment escalation. Dose escalation criteria were summarised and reported as observed in all patients who met escalation criteria at each time point. Over 70% of patients who qualified to receive ADA at randomisation met three to four criteria (Table). After randomisation, approximately 50% or more patients were escalated to the next treatment option based on one criterion. FC was the most frequent single reason of escalation followed by CRP and CDAI at 12 and 24 weeks. At 36 weeks, there were fewer escalations to which FC, CRP, and CDAI contributed equally. Among two reasons for escalation, the FC+CRP combination was the most prevalent. Overall, prednisone use was the least frequent criterion for escalation. Number of patients in the TC group who met escalation criteria at and after randomisation. The data from CALM suggest that biomarkers are important for guiding treatment decisions in patients with early CD after their symptoms are controlled by treatment. These results underscore the importance of monitoring biomarkers along with clinical symptoms to achieve better clinical and endoscopic outcomes. 1. Colombel J-F, et al. Lancet [published online on October 31]

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.